| Some natural flavonoids are competitive inhibitors of Caspase-1, -3 and -7 despite their cellular toxicity. | |
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MedLine Citation:
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PMID: 22140296 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A common feature of both apoptosis and inflammation is the activation of caspases. Caspases are aspartate-directed cysteine proteases that have numerous cellular targets. It has been discovered that several flavonoids are inhibitors of caspases. Flavonoids are members of a family of polyphenolic compounds from plants that have many biological properties, one of which is the ability to induce cell death. Some flavonoids are selective inhibitors of particular caspases. Since some of the inhibitory flavonoids are nevertheless cytotoxic, these results suggest that flavonoid-induced cell death may be occurring through a non-classical apoptosis pathway that is not dependent on caspase activity. |
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Authors:
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J Brandon White; Jeremy Beckford; Sina Yadegarynia; Nhi Ngo; Tetiana Lialiutska; Marc d'Alarcao |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Food chemistry Volume: 131 ISSN: 0308-8146 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702639 Medline TA: Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: 1453-1459 Citation Subset: - |
Affiliation:
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Department of Biological Sciences, San José State University, One Washington Square, San Jose, CA 95192-0100. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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SC3 GM084819-01//NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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