Document Detail


Some microbiological, histopathological and immunohistochemical characteristics of progressive periodontal disease.
MedLine Citation:
PMID:  7852619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present investigation was to study the local nature of human periodontal disease by assessing the microbiota and the composition of the tissue lesions at sites with progressive attachment loss in periodontitis susceptible subjects. 300 subjects with periodontal disease were monitored for 2 years without treatment. 8 subjects lost > 2 mm of attachment at > or = 3 sites during both the first and the second 12 month interval. These 8 subjects (progressive disease group; PD) were recalled for a microbiological and histopathological examination. A group of age- and sex-matched subjects were identified who during the 2 years of monitoring exhibited gingivitis and deep pockets, but no further attachment loss. This group of 11 subjects (non-progressive disease group; NPD) served as controls. From the 8 active disease subjects, > or = 1 interproximal site which had displayed disease activity (progressive disease active; PDA) and > or = 1 contralateral site without disease progression (progressive disease inactive; PDI) were sampled. From the 11 control subjects, 1 site/subject was sampled (NPD). The total number of viable micro-organisms (TVC) in the subgingival microbiota was estimated and a series of bacterial species were identified and enumerated. The gingival tissue of the sampling site was excised and the soft tissue prepared for morphometrical and immunohistochemical analyses. No differences were observed in the subgingival microbiota of the sample sites in the subjects who exhibited disease progression (PD) when compared with the subjects with periodontally diseased but stable conditions (NPD).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
B Liljenberg; J Lindhe; T Berglundh; G Dahlén; R Jonsson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  21     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  720-7     Citation Subset:  D; IM    
Affiliation:
Department of Periodontology, Faculty of Odontology, University of Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
B-Lymphocytes / pathology
Campylobacter / isolation & purification
Capnocytophaga / isolation & purification
Case-Control Studies
Colony Count, Microbial
Disease Progression
Follow-Up Studies
Fusobacterium nucleatum / isolation & purification
Gingiva / metabolism,  pathology
Gingivitis / metabolism,  microbiology,  pathology
Humans
Immunohistochemistry
Middle Aged
Periodontal Attachment Loss / metabolism,  microbiology,  pathology
Periodontal Diseases / metabolism,  microbiology*,  pathology*
Periodontal Pocket / metabolism,  microbiology,  pathology
Periodontitis / metabolism,  microbiology,  pathology
Plasma Cells / pathology
Prevotella intermedia / isolation & purification
T-Lymphocytes / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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