Document Detail

Some immunohormonal changes in experimentally pregnant toxemic goats.
MedLine Citation:
PMID:  20613964     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Pregnancy toxemia was induced in nine pregnant goat does with twins by the stress of fasting with access to water in late pregnancy to investigate the effect of pregnancy toxemia on immunoglobulins (IgA, IgM, and IgG), cortisol, insulin, thyroid, and growth hormones and their correlations with the plasma levels of glucose and beta-Hydroxybutyrate. Plasma samples were collected at 0, 12, 24, 36, 48, and 72 hours after induction of pregnancy toxemia. The result revealed that experimental animals developed neurological findings with convulsions and acetone odor from the mouth with recumbency after 72 hours. Laboratory findings showed a significant increase in beta-Hydroxybutyrate, cortisol, and insulin while there were significant decreases in glucose, thyroid, and immunoglobulins (IgA, IgM, and IgG). Plasma glucose concentrations had significant negative correlations with beta-hydroxybutyrate, cortisol, and insulin while the correlations were significantly positive with immunoglobulins and thyroid hormone. Plasma beta-hydroxybutyrate concentration was significantly positively correlated with cortisol and negatively correlated with immunoglobulins, insulin, and thyroid hormone. From this study we can conclude that pregnancy toxemia might affect humoral immune responses as well as insulin, cortisol, and thyroid hormones. Moreover, insulin might have a compensatory role to increase suppressive effect on ketogenesis in experimentally pregnant toxemic goats.
Abd-Elghany Hefnawy; Seham Youssef; Saad Shousha
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Publication Detail:
Type:  Journal Article     Date:  2010-06-16
Journal Detail:
Title:  Veterinary medicine international     Volume:  2010     ISSN:  2042-0048     ISO Abbreviation:  Vet Med Int     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-08     Completed Date:  2011-07-14     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  101524203     Medline TA:  Vet Med Int     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  768438     Citation Subset:  -    
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