Document Detail

Some food toxic for pets.
Jump to Full Text
MedLine Citation:
PMID:  21217849     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
According to world statistics, dogs and cats are the species that owners most frequently seek assistance with potential poisonings, accounting 95-98% of all reported animal cases. Exposures occur more commonly in the summer and in December that is associated with the holiday season. The majority (>90%) of animal poisonings are accidental and acute in nature and occur near or at the animal owner's home. Feeding human foodstuff to pets may also prove dangerous for their health.The aim of this review was to present common food items that should not be fed (intentionally or unintentionally) to dogs, i.e. chocolate, caffeine, and other methylxanthines, grapes, raisins, onion, garlic, avocado, alcohol, nuts, xylitol contained in chewing gum and candies, etc. Onion and avocado are toxic for cats, too. The clinical effects of individual toxicants and possible therapy are also mentioned. Knowing what human food has the potential to be involved in serious toxicoses should allow veterinarians to better educate their clients on means of preventing pet poisonings.It can be concluded that the best advice must surely be to give animal fodder or treats specifically developed for their diets.
Authors:
Natália Kovalkovičová; Irena Sutiaková; Juraj Pistl; Václav Sutiak
Related Documents :
22136129 - Acrylamide in foods: a review of the science and future considerations.
18989139 - Oesophageal bolus transit and clearance by secondary peristalsis in normal individuals.
21186759 - Potential risk of exposure to selected xenobiotic residues and their fate in the food c...
24698989 - Perceptions and choices of brazilian children as consumers of food products.
2751329 - Management of oesophageal stenosis in epidermolysis bullosa dystrophica.
9200289 - Self-reported food intolerance in chronic inflammatory bowel disease.
24140429 - Moving beyond energy homeostasis: new roles for glucagon-like peptide-1 in food and dru...
22843579 - Complete genome sequence of the opportunistic food-borne pathogen cronobacter sakazakii...
17655179 - Airborne allergenic pollen in natural areas: hornachuelos natural park, cordoba, southe...
Publication Detail:
Type:  Journal Article     Date:  2009-09-28
Journal Detail:
Title:  Interdisciplinary toxicology     Volume:  2     ISSN:  1337-9569     ISO Abbreviation:  Interdiscip Toxicol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101528175     Medline TA:  Interdiscip Toxicol     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  169-76     Citation Subset:  -    
Affiliation:
University of Veterinary Medicine, Komenského 73, 041 81 Košice, Slovak Republic.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Interdiscip Toxicol
Journal ID (publisher-id): ITX
ISSN: 1337-6853
ISSN: 1337-9569
Publisher: Slovak Toxicology Society SETOX
Article Information
Download PDF
Copyright©2009 Slovak Toxicology Society SETOX
open-access:
Received Day: 15 Month: 7 Year: 2009
Revision Received Day: 27 Month: 8 Year: 2009
Accepted Day: 28 Month: 8 Year: 2009
Print publication date: Month: 9 Year: 2009
Electronic publication date: Day: 28 Month: 9 Year: 2009
Volume: 2 Issue: 3
First Page: 169 Last Page: 176
ID: 2984110
PubMed Id: 21217849
Publisher Id: ITX-2-169
DOI: 10.2478/v10102-009-0012-4

Some food toxic for pets
Natália Kovalkovičová1
Irena Šutiaková2
Juraj Pistl1
Václav Šutiak1
1University of Veterinary Medicine, Komenského 73, 041 81 Košice, Slovak Republic
2University of Prešov, Ul. 17. Novembra 1, 081 16 Prešov, Slovak Republic
Correspondence: Correspondence address: Natália Kovalkovičová, DVM., PhD., University of Veterinary Medicine, Komenského 73, 041 81 Košice, Slovak Republic. TEL: +421915984674; E-MAIL: kovalkovicova@uvm.sk

Introduction

There is an unlimited number of agents by which exposed animals may become poisoned, and for the most part, which specific agents are involved in animal poisonings will be dependent upon what is available in the animals' environment, the potential or inclination for the animal to be exposed to the agent, the amount of agent to which the animal is exposed, and the individual sensitivity of the animal to the effects of the agent (Gupta, 2007).

Nowadys, the most common agents involved in animal exposures are rodenticides, chocolate, pharmaceuticals, glycols, metals, pesticides, plants, miscellaneous agents. Rodenticides, chocolate (approximately one quarter of all exposures) and pharmaceuticals (22% of exposures) make up the majority of agents in the most recent reports (Cope et al., 2006; Martinez-Haro et al., 2008). Feeding human foodstuff to pets may also prove dangerous for their health.

A difference between species regarding the occurrence of poisonings was found and such fact can be explained by different behaviour between dogs and cats.

Perhaps at least partly because of their inquisitive natures and willingness to investigate everything with their mouths, dogs far outrank other species when it comes to owners seeking aid for potential poisonings, making up 70–80% of all animal cases (Gupta, 2007). There are also some foods, which are edible for humans, and even other species of animals, that can pose hazards for dogs because of their different metabolism, e.g. chocolate, caffeine and other methylxanthines, grapes, raisins, onion, garlic, avocado, alcohol, nuts, etc.

Due, perhaps, to the more discriminating habits and appetites, cats account for only 11–20% of reported animal exposures to potential toxicants, which is three times less frequent than dogs. The cats are independent and less restrict to a definite space. Consequently, they are more susceptible to become victims of poisoning when tasteless and odorless toxic agents are mixed with tasty foods. In spite of being very selective in their alimentary pattern, cats can not notice the presence of the poison mixed with food, as insecticide aldicarb that is often mixed with fish that has strong odour and flavour (Xavier et al., 2007). Cats may due to their grooming habits, be more susceptible to toxicants that come into contact with their fur, this is especially problematic with agents to which cats are exquisitely sensitive (e.g. ethylene glycol) (Gupta, 2007). The most common poisonous foods for cats are onion and garlic and other related root vegetables, green tomatoes, green raw pottatoes, chocolate, grapes and raisins, etc.

Some food may cause only mild digestive upsets, whereas, others can cause severe illness, and even death in pets. Knowing what agents have the potential to be involved in serious toxicoses should allow veterinarians to better educate their clients on means of preventing animal poisonings through the appropriate use of household products and the removal of potential hazards from the animals' environments.


Chocolate, caffeine and other methylxanthines

Chocolate is derived from the roasted seeds of Theobroma cacao and its toxic principles are the methylxanthines theobromine (3,7-dimethylxanthine) and caffeine (1,3,7-trimethylxanthine). Theobromine is also found in tea, cola beverages, and some other foods.

Chocolate toxicoses occur especially at holidays: Valentine's day, Easter, Halloween, and Christmas and may result in potentially life-threatening cardiac arrhythmias and CNS dysfunction (Stidworthy et al., 1997; Beasley, 1999).

Sources

Most poisonings from methylxanthines occur as a result of chocolate ingestion. Chocolate is toxic to all species, especially to smaller dogs, though a toxic dose will vary depending on factors like whether the dog ate the chocolate on an empty stomach, if the dog is particularly sensitive to chocolate, and the type of chocolate, since dark chocolate is more toxic, whereas milk chocolate less so, and white chocolate must be consumed in extremely large quantities to cause a serious problem. Contributing factors include indiscriminate eating habits and readily available sources of chocolate. Deaths have also been reported in livestock fed cocoa byproducts and in animals consuming mulch from cocoa-bean hulls. Cocoa bean hulls or waste used as bedding for animals has caused toxicosis primarily in horses. Third most prevalent poisoning from these agents is a result of caffeine tablets ingested by dogs or hype race horses (tablets often contain 100 mg each). Theophylline tablets or elixirs are also used as human or veterinary medication.

The methylxanthine content

The most important toxic component of chocolate – the methylxanthine alkaloid theobromine is present in variable concentrations dependent on the quality of the chocolate – the darker or richer in cocoa solids the more dangerous the preparation. Cocoa powder and cooking chocolate are the most toxic forms (Sutton, 1981). Table 1 shows the total methylxanthine concentration in chocolate (www.merckvetmanual.com).

The amount of theobromine found in chocolate is small enough that chocolate can be safely consumed by humans in large quantities, but animals that metabolize theobromine more slowly can easily consume enough chocolate to cause poisoning. Although the concentration of theobromine in chocolate is 3–10 times that of caffeine, both constituents contribute to the clinical syndrome seen in chocolate toxicosis.

Toxic doses

A 10-kilogram dog can be seriously affected if it eats a quarter of a 250 g packet of cocoa powder or half of a 250 g block of cooking chocolate. These forms of chocolate contain ten times more theobromine than milk chocolate. Thus, a chocolate mud cake could be a real health risk for a small dog. Even licking a substantial part of the chocolate icing from a cake can make a dog unwell. A dog needs to eat more than a 250 g block of milk chocolate to be affected. Obviously, the smaller the dog, the less it needs to eat. A typical 20 kg dog will normally experience intestinal distress after eating less than 240 g of dark chocolate, but will not necessarily experience bradycardia or tachyarrhythmia unless it eats at least a half a kilogram of milk chocolate. According to the Merck Veterinary Manual (1998), approximately 1.3 g/kg b.wt. of baker's chocolate is sufficient to cause symptoms of toxicity, e.g. a typical 25 g baker's chocolate bar would be enough to bring out symptoms in a 20 kg dog.

The negative effects depend on the dosage, the size of the dog, and the type of chocolate. LD50 of methylxanthines in animals are summarised in Table 2 (www.actionagainstpoisoning.com).

Absorption, distribution, metabolism, excretion (ADME)

Theobromine and caffeine are readily absorbed from the GI tract and are widely distributed throughout the body. They are metabolized in the liver and undergo enterohepatic recycling and then excreted in the urine as both metabolites and unchanged parent compounds. Methylxanthines also readily pass in the milk of exposed lactating animals. Very little parent compound is passed in the feces. The half-lives of theobromine and caffeine in dogs are 17.5 h and 4.5 h, respectively.

Mechanism of action

Methylxanthines cause a competitive antagonism of cellular adenosine receptors. Inhibition of adenosine receptors causes CNS stimulation, constriction of some blood vessels, diuresis, and tachycardia. Methylxanthines also increase intracellular calcium levels by increasing cellular calcium entry and inhibiting intracellular sequestration of calcium by the sarcoplasmic reticulum of striated muscles. The net effect is increased strength and contractility of skeletal and cardiac muscle. Methylxanthines may also compete for benzodiazepine receptors within the CNS and inhibit phosphodiesterase, resulting in increased cyclic adenosine monophosphate (AMP) levels. They may also increase circulating levels of epinephrine and norepinephrine (www.merckvetmanual.com).

Clinical signs

Clinical signs of toxicosis usually occur within 6–12 h of ingestion, e.g. nausea, vomiting, diarrhoea, dyspnoe, thirst, and increased urination. These can progress to dehydration, restlessness, hyperactivity, cardiac arrhythmias, internal bleeding, heart attacks, tachypnea, ataxia, tremors, seizures, weakness, coma, cyanosis, hypertension, hyperthermia, and eventually death. The high fat content of chocolate products may trigger pancreatitis in susceptible animals. In general, mild signs (vomiting, diarrhoea, polydipsia) may be seen in dogs ingesting 20 mg/kg, cardiotoxic effects may be seen at 40–50 mg/kg, and seizures may occur at doses ≥60 mg/kg (www.merckvetmanual.com). A dog, which ingested a lethal quantity of garden mulch made from cacao bean shells, developed severe convulsions and died 17 h later. Analysis of the stomach content and the ingested cacao bean shells revealed the presence of lethal amounts of theobromine (Drolet et al., 1984).

Treatment

Once animals have stabilized, or in animals presenting before clinical signs have developed (e.g. within 1 h of ingestion), decontamination should be performed. Induction of emesis using apomorphine (0.08 mg/kg i.m. or s.c.) or hydrogen peroxide should be initiated; in animals that have been sedated due to seizures, gastric lavage may be considered. Activated charcoal (1–4 g/kg, p.o.) should be administered; because of the enterohepatic recirculation of methylxanthines, repeated doses should be administered every 3 h for up to 72 h in symptomatic animals (control vomiting with metoclopramide, 0.2–0.4 mg/kg, s.c. or i.m.). Erythromycin and corticosteroids should be avoided because they interfere with excretion of methylxanthines. For ventricular-origin tachyarrythmias lidocaine is applicated (1–2 mg/kg i.v. until effect, followed by 25–80 mg/kg/min infusion rate to effect to maintain). However, lidocaine cannot be used in cats. If lidocaine fails, metoprolol injection is preferred over propranolol, since metoprolol does not slow renal excretion of methylxanthines as propranolol can. Suggested starting dose for injectable form of either metoprolol or propranolol is 0.02–0.06 mg/kg slow i.v., which can be repeated and increased if needed. The rate of administration should not exceed 1 mg/2 min i.v. For bradycardia (less prevalent) atropine is used at 0.01–0.02 mg/kg i.m. or s.c. Artificial respiration is applicated if needed. To release seizures diazepam (0.5–2.0 mg/kg, slow i.v.) or barbiturates are applicated. Fluid diuresis may assist in stabilizing cardiovascular function and hasten urinary excretion of methylxanthines. Other treatment for symptomatic animals includes thermoregulation, correcting acid/base and electrolyte abnormalities, monitoring cardiac status via electrocardiography, and urinary catheter placement (methylxanthines and their metabolites can be reabsorbed across the bladder wall). Clinical signs may persist up to 72 h in severe cases.


Grapes, raisins and sultanas

One of the more striking poisonings to have emerged as a potential concern over the last few years has been that of raisin poisoning in dogs. The ingested doses involved in these fatal cases ranged from 10 to 57 g of fruit per kg b. wt. There are now several reports that confirm that ingestion of these fruits can cause renal failure in dogs. Grapes contain an unknown toxin (Gwaltney-Brant et al., 2001; Penny et al., 2003; Campbell and Bates, 2003; Mazzaferro et al., 2004, Sutton and Campbell, 2006, Campbell, 2007).

Mechanism of action

The toxic mechanism remains to be elucidated, and the apparent lack of a reproducible dose response relationship has led some authors to suggest this may reflect either a component of the fruits that is present in varying quantities, or the existence of an extrinsic compound that may not always be present. Individual variations in response may also occur (McKnight, 2005).

Toxic doses

The general consensus at present is that potentially any dose should be considered a problem. Estimated amounts of grapes associated with renal injury in dogs are about 32 g/kg; amounts of raisins associated with signs range from 11–30 g/kg (www.merckvetmanual.com).

Clinical signs

Clinical effects usually become apparent within 6 h of ingestion, and always within 24 h. Early signs are vomiting (in almost all cases), diarrhoea within 6–12 h of ingestion, anorexia, abdominal pain, weakness, dehydration, tremors and lethargy. Ingesta may be present in the vomitus or faeces. Polydipsia may also be apparent. Oliguric or anuric renal failure develops within 24–72 h of exposure; once anuric renal failure develops, most dogs die or are euthanized. Urinalysis may reveal proteinuria, glucosuria, microscopic haematuria and, rarely, crystalluria. Urine and blood tests will provide definitive evidence for it. Transient elevations in serum glucose, calcium, phosphorus, liver and pancreatic enzymes develop in some dogs (Eubig et al., 2005). It is generally agreed that prognosis in dogs with oliguria or anuria is poor.

Necropsy

In some of the cases with fatal outcomes proximal renal tubule necrosis and renal calcification was described (Morrow et al., 2005).

Therapy

Ingestion of any quantity of grapes, raisins or sultanas by a dog should be considered treatable. Digestion of the fruits appears to be slow and decontamination several hours post-ingestion may be worthwhile as whole grapes and swollen raisins have been recovered after remaining in the stomach overnight. Gut decontamination should be considered by means of emesis or gastric lavage. Emesis can be induced with 3% hydrogen peroxide (2 ml/kg; no more than 45 ml), followed by activated charcoal. Activated charcoal may be of benefit, but care should be taken to ensure bowel sounds are regular before this is administered. If spontaneous vomiting is protracted it must be consider to use anti-emetics such as metoclopramide (0.5–1 mg p.o., s.c. or i.m. 6–8 h or 1–2 mg/kg per day by slow i.v. injection). Aggressive i.v. fluid therapy for at least 48 h for rehydration and support of renal function is important (Campbell, 2007). Renal function and electrolytes should be monitored for at least 72 h post-ingestion. Where necessary the use of furosemide (2 mg/kg i.v. initially followed by i.v. infusion of 5 mg/kg/h), dopamine (0.5–3 μg/kg/min, i.v.) or mannitol (0.25–0.5 g/kg i.v. over 5–10 min) may be considered to re-establish urine output in oliguric dogs (McKnight, 2005). However, the efficacy of these therapies remains unproven and that there is evidence that tubular necrosis or renal tubule obstruction may prevent urine flow. Anuric dogs are unlikely to survive unless peritoneal dialysis or hemodialysis is performed, and even then the prognosis is guarded.


Onion toxicosis

The onion (Allium cepa) is one of the oldest crops. Its world production has increased by at least 25% over the past 10 years with current production being around 44 million tonnes making it the second most important horticultural crop after tomatoes. Because of its storage characteristics and durability for shipping, onion has always been traded more widely than most vegetables. Onion is versatile and is often used as an ingredient in many dishes and is accepted by almost all traditions and cultures. Onion consumption is increasing significantly and this is partly because of heavy promotion that links flavour and health. Onion is rich in two chemical groups that have perceived benefits to human health – flavonoids and alk(en)yl cysteine sulphoxides. Apart from its culinary uses – fresh, cooked or dehydrated – medicinal properties have been attributed to both since ancient times, prompting in recent years an accurate chemical analysis of the most characteristic active ingredients. Compounds from onion have a range of health benefits which include anticarcinogenic properties, antiplatelet, antithrombotic activity, antiasthmatic, antidiabetic, hypocholesterolaemic, fibrinolytic and various other biological actions, and antibiotic effects (Augusti, 1996; Briggs et al., 2001; Griffiths et al., 2002; Slimestad et al., 2007). On the other hand, onion contains the toxic components which can damage red blood cells and cause haemolytic anaemia accompanied by the formation of Heinz bodies in erythrocytes of animals (Desnoyers, 2000), e.g. in cattle (Carbery, 1999; Rae, 1999; Van Der Kolk, 2000), horses (Thorp and Harshfielf, 1939), dogs (Stallbaumer, 1981; Harvey and Rackear, 1985; Solter and Scott, 1987; Yamato et al., 2005) and cats (Kobayashi, 1981).

Heinz body anaemia is an uncommon finding in dogs, and few other toxicants, e.g. methylene blue, acetaminophene, zinc, benzocaine, vitamin K, phenylhydrazine (Houston and Myers, 1993) can induce it, so onion ingestion must always be suspected in such situations.

Mechanism of action

Various factors are implicated in the wide variation in species susceptibility, including differences in hemoglobin structure and protective enzyme systems. The mechanism of onion toxicity has been known for several decades, but recent studies have shown that more than one toxin is involved. The toxic components in all type of onions, garlic, leeks, shallots, and other plants of the Allium family, are sulfoxides and aliphatic sulfides, specifically allyl and propyl di-, tri-, and tetrasulfides. Onions contain also the relatively rare amino acids S-meth and S-prop (en)ylcysteine sufoxides (SMCO). It is widely agreed that n-propyl disulphide is the principal toxin that reduces the activity of glucose-6-phosphate dehydrogenase in red blood cells; thereby interfering with regeneration of reduced glutathione needed to prevent oxidative denaturation of haemoglobin (Thrall, 2004). Denaturated haemoglobin, when developed, precipitates on the surface of red blood cells (named Heinz bodies) and triggers intra- and extravascular haemolysis (Lincoln et al., 1992; Tang et al., 2008). The haemolytic effect of sodium n-propylthiosulphate, which had been isolated from boiled onions, was studied in dogs by Yamato et al. (1998). The oral administration of 500 mumol/kg b. wt. of the compound to dogs resulted in a haemolytic anaemia associated with an increase of Heinz body formation in erythrocytes, which was more severe in dogs with the hereditary condition which results in erythrocytes with high concentrations of reduced glutathione and potassium than in normal dogs. In the affected dogs there was a 10-fold increase in the concentration of oxidised glutathione in their erythrocytes 12 h after the administration of the compound, whereas in normal dogs there was almost no change.

Toxicity

Consumption of as little as 5 g/kg of onions in cats or 15 to 30 g/kg in dogs has resulted in clinically important hematologic changes (Cope, 2005). Onion toxicosis is consistently noted in animals that ingest more than 0.5% of their b. wt. in onions at one time. A relatively high dosage (600–800 g) in one meal or spread apart over a few days can damage red blood cells and cause haemolytic anaemia accompanied by the formation of Heinz bodies in erythrocytes.

All forms of onion can be a problem including: dehydrated, raw or cooked onions, table scraps containing cooked onions or garlic, left over pizzas, chinese dishes, any feeding stuff containing onions.

Humans are the most resistant species studied. On the other hand, there is some concern about the susceptibility of certain ethnic groups that have a genetic deficiency of glucose-6-phosphate dehydrogenase.

Although the dog appears to be one of the most susceptible species, there are very few reports in the scientific literature concerning accidental canine poisoning associated with onion ingestion. Cats are more susceptible than dogs. Since baby food is often used in sick cats that are not eating (to stimulate their appetite), there was concern that the onion powder would cause a Heinz body anemia in these cats (Robertson et al., 1998). Many baby food manufacturers add onions or onion powder to increase palatability. It is generally accepted that sheep, goats, rats and mice are more resistant to onion toxicosis than other domestic animals (Thrall, 2004; Aslani et al., 2005). The safety of feeding culled onions to livestock depends upon species susceptibility and the toxic potential of the onions. Sheep can be maintained on diets of up to 50% onions with no clinical abnormalities or detrimental effects on growth. Even when onions are fed free choice, sheep have only transient hemoglobinuria and anemia, with few deaths even reported. In contrast, cattle should be fed onions with caution, due to the relative susceptibilty of their erythrocytes to oxidative damage. Daily feeding of onions could have a cumulative effect due to ongoing formation of Heinz bodies versus a single exposure with a wide gap until the next exposure, allowing the bone marrow time to regenerate the prematurely destroyed red cells.

Clinical signs

The first symptoms are usually of gastro-enteritis: vomiting, diarrhoea, abdominal pain, loss of appetite, depression and dehydration. It will take a few days for the dog to display the symptoms associated with the loss of red blood cells: pale mucous membranes, rapid respiratory rate, difficulty to breath, lethargy, dark coloured urine – reddish or brown, jaundice, weakness, rapid heart rate. Haematology may reveal neutrophilia, lymphopenia, Heinz-body anaemia and methaemoglobinaemia.

Therapy

There is not any antidote, however, supportive care may be helpful: hospitalisation, administration of intra-venous fluids, blood transfusions. Treatment is advocated of ingestion of any quantity. For recent ingestions gastric decontamination should be considered, and use of adsorbents, but thereafter management is largely supportive. It is important that the animals remain hydrated; antiemetics may be given to control persistent vomiting. Nonenzymatic reductants such as ascorbic acid may also be useful (in dog 30 mg/kg b. wt. i.v. each 6–8 h). Antioxidant prevention (by N-acetylcysteine, vitamin E, ascorbate) of Heinz body formation and oxidative injury in cats was recommended by Hill et al. (2001). In severely poisoned animals blood transfusions have been successfully employed.

Nevertheless, even taking into account that lethal effects are infrequent in dogs, avoiding exposure to any kind of A. cepa in this and other domestic animal species seems to be the best preventive health strategy.


Garlic

Garlic (Allium sativum) is considered to be less toxic and safe for dogs than onion when used in moderation. Allicin and ajoene, pharmacologically active agents in garlic, are potent cardiac and smooth muscle relaxants, vasodilators, and hypotensive agents (Malik and Siddiqui, 1981; Mayeux et al., 1988; Martin et al., 1992). Lee et al. (2000) studied wether dogs given garlic extract developed hemolytic anemia. Garlic extract was administered intragastrically (1.25 ml/kg of b.wt. (5 g of whole garlic/kg) once a day for 7 days). Compared with initial values, erythrocyte count, haematocrit and hemoglobin concentration decreased to a minimum value on days 9 to 11. Heinz body formation, an increase in erythrocyte-reduced glutathione concentration, and eccentrocytes were also detected, however, no dog developed hemolytic anemia. Eccentrocytosis appears to be a major diagnostic feature of garlic-induced hemolysis in dogs (Lee et al., 2000; Yamato et al., 2005).

Garlic is toxic also for horses, at a daily dose of >0.2 g/kg causes Heinz body anemia in them (Pearson et al., 2005).


Avocado

Avocado fruit, pits, leaves and the actual plant are all potentially poisonous to dogs, along with other pets like cats, mice, rats, birds, rabbits, horses, cattle and goats, among others.

Persin is a fungicidal toxin found in both the fruit and leaves of the avocado tree (Persea americana). It has been isolated only recently and discovered to kill breast cancer cells. It has also been shown to enhance the effect of the breast cancer fighting drug Tamoxifen. This could potentially reduce the necessary dosage of current cancer drugs. Persin is however highly insoluble, and more research will be needed to put it into a soluble tablet form.

Feeding avocados to any non-human animal should be completely avoided. The lethal dose is not known; the effect is different depending upon the animal species. Avocados will trigger fluid accumulation in the lungs and chest, leading to difficulty breathing and death due to oxygen deprivation. Fluid accumulation can also occur in the heart, pancreas and abdomen (Buoro et al., 1994). High fat content of avocado can lead to pancreatitis.

Clinical signs

The symptoms include gastrointestinal irritation, vomiting, diarrhoea, respiratory distress, congestion, fluid accumulation around the tissues of the heart and even death. Birds seem to be particularly sensitive to this toxic compound and the symptoms are the increased heart rate, myocardial tissue damage, labored breathing, disordered plumage, unrest, weakness, and apathy. High doses cause acute respiratory syndrome (asphyxia), with death approximately 12 to 24 h after consumption. In lactating rabbits and mice non-infectious mastitis and agalactia after consumption of leaves or bark was observed. In rabbits cardial arrhythmia, submandibular edema and death after consumption of leaves occur. In cows, horses and goats mastitis after consumption of leaves or bark was observed.


Macadamia nuts

Macadamia nuts originate from the trees Macadamia integrifolia in the continental USA and Macadamia tetraphylla in Hawaii and Australia. They are commonly present in cookies, so owners should be careful what they feed their dog. Macadamia nuts (both raw and roasted) as well as macadamia butter contain an unknown toxin that affects the muscles, digestive system and nervous system and can cause locomotory difficulties, weakness, dyspnoe, tremors and swollen limbs. Macadamia nuts and walnuts can also trigger pancreatitis and peanuts a deadly allergic reaction (Knott et al., 2008).

The mechanism of action

The mechanism of toxicity is unknown; but may involve a constituent of the nuts, processing contaminants or mycotoxins.

Toxicity

The toxic dose to dogs ranges from 2.4–62.4 g per kg b.wt. This is a very large range and can mean that some dogs will get ill with just a small amount of nuts ingested, while other dogs need to eat a lot of nuts to show signs (Hansen et al., 2000).

Clinical signs

Dogs are the only species in which signs have been reported (www.merckvetmanual.com). Within 12 h of ingestion, dogs develop weakness (more pronounced in hind limbs), depression, vomiting, abdominal pain, ataxia, muscle tremors, swollen and painful limbs, paralysis of the hindquarters, hyperthermia (with rectal temperatures up to 40.5 °C), an elevated heart rate, lameness, stiffness and recumbency. Tremors may be secondary to muscle weakness. Macadamia nuts may be identified in vomitus or feces. Mild transient elevations in serum triglycerides, lipases, and alkaline phosphatase were reported in some dogs experimentally dosed with macadamia nuts; these values quickly returned to baseline by 48 h after experimental dosing (Hansen et al., 2000). Signs generally resolve within 12–48 h (Hansen et al., 2000; Hansen, 2002). The onset of clinical signs was reported as <12 h in 79% of the cases. The duration of clinical signs for the majority of cases was <24 h. The amount of macadamia nuts ingested was estimated in 72% of the calls with a mean of 11.7 g/kg bw. All field and experimental dogs recovered uneventfully within 1 to 2 d whether treated by a veterinarian or not. No mortality has been reported.

Therapy

For asymptomatic dogs with recent ingestion of more than 1–2 g/kg, emesis should be induced; activated charcoal may be of benefit with large ingestions. Fortunately, most symptomatic dogs will recover without any specific treatment. Severely affected animals may be given supportive treatment such as fluids, analgesics or antipyretics (www.merckvetmanual.com). Use of mild laxatives may assist the passage of ingesta through the gastrointestinal tract. Luckily, the muscle weakness, while painful, seems to be of short duration and the patients do recover from the toxicity.


Effects of xylitol ingestion

Xylitol, an artificial sweetener, is present in many products, such as candy, sugar-free chewing gums, toothpaste and baked goods. Ingestion of these foods by dogs results in a significant, and often sustained, insulin-mediated hypoglycemic crisis (Cope, 2004). In both humans and dogs, the levels of blood sugar are controlled by the body's release of insulin from the pancreas. In human xylitol ingestion does not cause any significant changes in insulin levels or, therefore, blood glucose (Dunayer, 2004). However, in dogs, xylitol is a strong promoter of insulin release, which results in a rapid decrease in blood glucose (hypoglycemia) (Asano et al., 1977; Dunayer, 2004; Campbell and Bates, 2008). A sudden drop in blood sugar then results in depression, ataxia, seizures and collapse (Thomas and Boag, 2008). This compound can cause liver damage and death. This information was first published in July 2004.

Clinical signs

Clinical signs of xylitol toxicity can develop in as few as 30 min after ingestion and may include one or more of the following: vomiting, weakness, ataxia, depression, hypokalemia, seizures, coma, liver dysfunction and/or failure. Dunayer and Gwaltney-Brant (2006) observed in dogs lethargy and vomiting after ingestion of xylitol. In addition some dogs had widespread petechial, ecchymotic, or gastrointestinal tract hemorrhages, moderately to severely high serum activities of liver enzymes, hyperbilirubinemia, hypoglycemia, hyperphosphatemia, prolonged clotting times, and thrombocytopenia. Necropsy revealed severe hepatic necrosis, hepatocyte loss or atrophy with lobular collapse.

Treatment

The induction of vomiting is recommended if performed very soon after ingestion of the xylitol-containing product but before clinical signs develop. Frequent small meals or an oral sugar supplement may be used to manage dogs that have not yet shown clinical signs. Following the appearance of clinical signs intravenous dextrose can be used to control hypoglycemia. It may also be necessary to treat the patient for hypokalemia, if indicated. Treatment should be continued until the blood glucose levels return to normal levels.

Dunayer and Gwaltney-Brant (2006) recommended for treatment i.v. administration of fluids; plasma transfusions; and, if indicated, administration of dextrose. Cope (2004) revealed that binding of xylitol to activated charcoal is relatively low; however, activated charcoal administration may still be beneficial in some canine acute oral xylitol exposures.


Alcohol toxicoses

Serious intoxications have occurred when dogs have been given alcohol to drink as a „joke“. Also, dogs seem to be attracted to alcoholic drinks, so drinks should not be left unattended. Dogs cannot tolerate alcohol, even in small amounts.

Ethanol is the alcohol in alcoholic beverages, perfumes and mouthwashes. Ethanol toxicosis in dogs occurred after ingestion of rotten apples (Kammerer et al., 2001), alcoholic beverages (van Wuijckhuise and Cremers, 2003) or uncooked bread dough that contains Saccharomyces cerevisiae (brewer's and baker's yeast), which metabolizes carbohydrate substates to ethanol and carbon dioxide (Thrall et al., 1984; Suter, 1992; Means, 2003). Ethanol toxicosis can also occur in dogs and cats after overdosage when ethanol is given intravenously as a compatitive substrate to treat ethylene glycol toxicosis (Thrall et al., 1998).

Mechanism of action

The mechanism of action on the CNS is related in part to its interactions with biomembranes and its probable inhibition of gamma-amino butyric acid (GABA) receptors (Valentine, 1990).

Clinical signs

Clinical signs include ataxia, lethargy, sedation, hypothermia, metabolic acidosis, vomiting, diarrhoea, poor breathing, liver failure, coma, and death. And the hops in beer are also potentially toxic to dogs and cause dyspnoe, increased heart rate, elevated temperature, seizures and death.

Therapy

Severe ethanol intoxication requires mechanical ventilation. Electrolyte and acid-base status should be also corrected (Richardson, 2006).


Conclusion

There are also other human foods that may cause intoxications in pets, e.g. tomato, pottato, rhubarb, persimons, etc. The best advice must surely be to give animals foodstuffs and or treats specifically developed for their diets.


Acknowledgements

This study was supported by VEGA Grants No. 1/0545/08, 1/4375/07 and the National Reference Laboratory for Pesticides, University of Veterinary Medicine in Košice.


REFERENCES
Asano T,Greenberg BZ,Wittmers RV,Goetz FC. Xylitol, a partial homologue at alpha-D-glucopyranose: potent stimulator of insulin release in dogsEndocrinologyYear: 19771002339345832627
Aslani MR,Mohri ĆM,Movassaghi ĆAR. Heinz body anaemia associated with onion (Allium cepa) toxicosis in a flock of sheepComp Clin PathYear: 200514118120
Augusti KT. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.)Indian J Exp BiolYear: 19963476346408979497
Beasley V. Veterinary toxicologyBeasley VToxicants associated with stimulation or seizuresYear: 1999Ithaca NYInternational Veterinary information service 1999, Available from: http://www.ivis.org.
Briggs WH,Folts JD,Osman HE,Goldman IL. Administration of raw onion inhibits platelet-mediated thrombosis in dogsJ NutrYear: 20011312619262211584080
Buoro IB,Nyamwange SB,Chai D,Munyua SM. Putative avocado toxicity in two dogsOnderstepoort J Vet ResYear: 19946111071097898892
Campbell A,Bates N. Raisin poisoning in dogsVet RecYear: 20031521237612678272
Campbell A. Grapes, raisins and sultanas, and other foods toxic to dogsUK VetYear: 200712113
Campbell A,Bates N. Xylitol toxicity in dogsVet RecYear: 2008162825418296672
Carbery JT. A case of onion poisoning in a cowN Z Vet JYear: 19994718416032100
Cope RB. A screening study of xylitol binding in vitro to activated charcoalVet Hum ToxicolYear: 200446633633715587257
Cope RB. Allium species poisoning in dogs and catsVet MedYear: 2005562566
Cope RB,White KS,More E,Holmes K,Nair A,Chanvin P,Oucken A. Exposure-to-treatment interval and clinical severity in canine poisoning: a retrospective analysis at a Portland Veterinary Emergency CenterJ Vet Pharmacol TherapyYear: 200629233236
Desnoyers M. Fedman BF,Zinkl JG,Jain NCAnemias associated with Heinz bodiesSchalm's veterinary hematologyYear: 20005th edn.Baltimore,PhiladelphiaLippincott Williams & Wilkins178180
Drolet R,Arendt TD,Stowe CM. Cacao bean shell poisoning in a dogJ Am Vet Med AssocYear: 198418589026501051
Dunayer EK. Hypoglycemia following canine ingestion of xylitol-containing gumVet Hum ToxicolYear: 2004462878815080212
Dunayer EK,Gwaltney-Brant SM. Acute hepatic failure and coagulopathy associated with xylitol ingestion in eight dogsJ Am Vet Med AssocYear: 200622971113111717014359
Eubig P,Brady M,Gwaltney-Brant S,Khan S,Mazzaferro E,Morrow C. „Acute renal failure in dogs after the ingestion of grapes or raisins: a retrospective evaluation of 43 dogs (1992–2002)“J Vet Int MedYear: 2005195663674
Griffiths G,Trueman L,Crowther T,Thomas B,Smith B. Onions-a global benefit to healthPhytother ResYear: 200216760361512410539
Gupta RC. Veterinary Toxicology. Basic and Clinical PrinciplesYear: 2007Elsevier Ltd1201
Gwaltney-Brant S,Holding JK,Donaldson CW,Eubig PA,Khan SA. Renal failure associated with ingestion of grapes or raisins in dogsJ Am Vet Med AssocYear: 2001218101555155611393362
Hansen SR,Buck WB,Meerdink G,Khan SA. Weakness, tremors, and depression associated with macadamia nuts in dogsVet Hum ToxicolYear: 2000421182110670081
Hansen SR. Macadamia nut toxicosis in dogsVet MedYear: 2002972
Harvey JW,Rackear D. Experimental onion-induced hemolytic anemia in dogsVet PatholYear: 19852243873924035943
Hill AS,O'Neill S,Rogers QR. Antioxidant prevention of Heinz body formation and oxidative injury in catsAm J Vet ResYear: 20016237037411277202
Houston DM,Myers SL. A review of Heinz-body anemia in the dog induced by toxinsVet Hum ToxicolYear: 19933521581618470361
Kammerer M,Sachot E,Blanchot D. Ethanol toxicosis from the ingestion of rotten apples by a dogVet Hum ToxicolYear: 200143634935011757994
Knott E,Gürer CK,Ellwanger J,Ring J,Darsow U. Macadamia nut allergyJ Eur Acad Dermatol VenereolYear: 200822111394139518331311
Kobayashi K. Onion poisoning in the catFel PractYear: 1981112227
Lee KW,Yamato O,Tajima M,Kuraoka M,Omae S,Maede Y. Hematologic changes associated with the appearance of eccentrocytes after intragastric administration of garlic extract to dogsAm J Vet ResYear: 200061111446145011108195
Lincoln SD,Howell ME,Combs JJ,Hinman DD. Hematologic effects and feeding performance in cattle fed cull domestic onions (Allium cepa)J Am Vet Med AssocYear: 19922008109010941607313
Malik ZA,Siddiqui S. Hypotensive effect of freeze-dried garlic (Allium sativum) sap in dogJ Pak Med AssocYear: 19813112136782270
Martin N,Bardisa L,Pantoja C. Experimental cardiovascular depressant effects of garlic (Allium sativum) dialysateJ EthnopharmacolYear: 1992371451491434688
Martínez-Haro M,Mateo R,Guitart R,Soler-Rodríguez F,Pérez-López M,María-Mojica P,García-Fernández AJ. Relationship of the toxicity of pesticide formulations and their commercial restrictions with the frequency of animal poisoningsEcotoxicol Environ SafetyYear: 200869339640217570525
Mayeux PR,Agrawal KC,Tou JS. The pharmacological effects of allicin, a constituent of garlic oilAgents ActionsYear: 1988251821902847508
Mazzaferro EM,Eubig PA,Hackett TB,Legare M,Miller C,Wingfield WE,Wise L. Acute renal failure associated with raisin or grape ingestion in 4 dogsJ Vet Emerg Crit CareYear: 2004143196202
McKnight K. Grape and raisin toxicity in dogsVet TechnicYear: 2005135136
Means C. Bread dough toxicosis in dogsJ Vet Emerg Crit CareYear: 200333941
Morrow C,Valli V,Volmer P,Eubig P. „Canine renal pathology associated with grape or raisin ingestion: 10 cases“J Vet Diag InvestYear: 2005173223231
Pearson W,Boermans HJ,Bettger WJ,McBride BW,Lindinger MI. Association of maximum voluntary dietary intake of freeze-dried garlic with Heinz body anemia in horsesAm J Vet ResYear: 200566345746515822591
Penny D,Henderson SM,Brown PJ. Raisin poisoning in a dogVet RecYear: 20031521030812650485
Rae HA. Onion toxicosis in a herd of beef cowsCan Vet JYear: 19994055579919370
Richardson JA. Peterson M,Talcott PEthanolSmall Animal ToxicologyYear: 2006St. Luis, MOElsevier Saunders698701
Robertson JE,Christopher MM,Rogers QR. Heinz body formation in cats fed baby food containing onion powderJ Am Vet Med AssocYear: 19982128126012669569166
Slimestad R,Fossen T,Vågen IM. Onions: a source of unique dietary flavonoids. 1J Agric Food ChemYear: 20075525100671008017997520
Solter P,Scott R. Onion ingestion and subsequent Heinz body anemia in a dog: a case reportJ Am Anim Hosp AssocYear: 198723544546
Stallbaumer M. Onion poisoning in a dogVet RecYear: 19811085235247257143
Stidworthy MF,Bleakley JS,Cheeseman MT,Kelly DF. Chocolate poisoning in dogsVet RecYear: 19971411289248028
Suter RJ. Presumed ethanol intoxication in sheep dogs fed uncooked pizza doughAust Vet JYear: 1992691201554340
Sutton RH. Cocoa poisoning in a dogVet RecYear: 198110925–265635647336548
Sutton N,Campbell A. Grape poisoning in dogs-a case series from the Veterinary Poisons Information Service, LondonClin ToxYear: 2006444526527
Tang X,Xia Z,Yu J. An experimental study of hemolysis induced by onion (Allium cepa) poisoning in dogsJ Vet Pharmacol TherYear: 200831214314918307506
The Merck Veterinary ManualChocolate poisoningYear: 19988th ed.CZ/SK2029
Thomas H,Boag A. What is your diagnosis? HypoglycaemiaJ Small Anim PractYear: 2008491474918173775
Thorp FJ,Harshfielf GS. Onion poisoning in horsesJ Am Vet Med AssocYear: 19399452053
Thrall MA,Freemyer FG,Hamar DW,Jones RL. Ethanol toxicosis secondary to sourdough ingestion in a dogJ Am Vet Med AssocYear: 198418412151315146539765
Thrall MA,Commaly HE,Grauer GF. Don't freezeup! Quick response is key in ethylene glycol poisoningVet TechYear: 199819557567
Thrall MA. Veterinary hematology and clinical chemistryYear: 2004PhiladelphiaWilliams & Wilkins618
Valentine WM. Toxicology of selected pesticides, drugs, and chemicals. Short-chain alcoholsVet Clin North Am Small Anim PractYear: 19902025155232180193
Van Der Kolk JH. Onion poisoning in a herd of dairy cattleVet RecYear: 200014751751811110494
van Wuijckhuise L,Cremers GG. Alcohol poisoning in dogsTijdschr DiergeneeskdYear: 2003128928428512769038
Xavier FG,Righi DA,de Souza Spinosa H. Fatal poisoning in dogs and cats – A 6-year report in a veterinary pathology service.Braz J Vet Res Anim Sci, São PauloYear: 2007444304309
Yamato O,Hayashi M,Yamasaki M,Maede Y. Induction of onion-induced haemolytic anaemia in dogs with sodium n-propylthiosulphateVet RecYear: 199814292162199533293
Yamato O,Kasai E,Katsura T,Takahashi S,Shiota T,Tajima M,Yamasaki M,Maede Y. Heinz body hemolytic anemia with eccentrocytosis from ingestion of Chinese chive (Allium tuberosum) and garlic (Allium sativum) in a dogJ Am Anim Hosp AssocYear: 2005411687315634869

Tables
[TableWrap ID: T0001] Table 1 

The total methylxanthine concentration in chocolate (www.merckvetmanual.com).


Type of product The total methylxanthine concentration
dry cocoa powder 28.5 mg/g
unsweetened (baker's) chocolate 16 mg/g
cocoa bean hulls 9.1 mg/g; 0.5–0.85% theobromine
semisweet chocolate and sweet dark chocolate 5.4–5.7 mg/g
milk chocolate 2.3 mg/g
refined chocolate candies 1.4–2.1 g/kg
white chocolate an insignificant source of methylxanthines
cocoa beans 1–2% theobromine

[TableWrap ID: T0002] Table 2 

LD50 of methylxanthines in animals (www.actionagainstpoisoning.com).


Methylxanthine Animal LD50 (mg/kg)
Theophylline Dog 300
Cat 700
Caffeine Dog 140
Theobromine Dog 250–500
Cat 200
Mouse 837
Rat 1 265


Article Categories:
  • Review Article

Keywords: pet, human food, intoxication.

Previous Document:  Toxicological risk of melamine and cyanuric acid in food and feed.
Next Document:  Can thiol compounds be used as biomarkers of aquatic ecosystem contamination by cadmium?