Document Detail


Some excitatory and inhibitory factors involved in the epileptic state.
MedLine Citation:
PMID:  8250154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many factors are involved in the determination of the epileptic threshold and the precipitation of epileptic seizures. The balance between the underlying excitatory and inhibitory mechanisms are often imperfectly understood. However, some of these factors must be fully considered if the management of those with epilepsy is to be effective. This applies especially to children. Certain types of epilepsy are genetically determined, and others are age-related. Development of the brain plays a crucial role in the changing liability to epilepsy. If these processes are disturbed by various lesions and diseases, such as metabolic and toxic disorders, protective mechanisms may suffer. Kindling and mirror foci, the role of the cerebellum, and reflex epilepsy will be discussed. There are some seizure-inducing factors which are susceptible to change, and can be as important as anti-epileptic drugs in controlling seizures. The use and limitations of these measures, and of drugs, will be considered.
Authors:
R B Aird; N S Gordon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Brain & development     Volume:  15     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:    1993 Jul-Aug
Date Detail:
Created Date:  1993-12-29     Completed Date:  1993-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Anticonvulsants / therapeutic use
Brain / growth & development
Cerebellum / physiopathology
Child, Preschool
Epilepsy / genetics,  physiopathology*,  therapy
Humans
Kindling, Neurologic
Neural Inhibition*
Reflex
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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