| Some evidences for the hypothesis of active transport of streptomycin in Pseudomonas aeruginosa. | |
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MedLine Citation:
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PMID: 821724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New evidence is presented in support of the hypothesis put forth by CAMBA et al. [1] that streptomycin enters bacterial cells by a process of active transport. In this paper a general inhibitor of transport, uranyl nitrate, when added to the bacterial suspension prior to the addition of streptomycin, was shown to significantly increase the resistance to the drug. Furthermore, in suspensions of cells with a progressively exhausted endogenous metabolism and consequently with less available energy, a corresponding increase in the amount of streptomycin remaining in the supernatant was observed. |
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Authors:
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S A Camba; F Alterthum; L P De Carvalho Lima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 22 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 1976 |
Date Detail:
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Created Date: 1976-11-01 Completed Date: 1976-11-01 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 341-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Transport, Active
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drug effects Cell Wall / metabolism Pseudomonas aeruginosa / metabolism* Streptomycin / administration & dosage, metabolism* Uranyl Nitrate / pharmacology |
| Chemical | |
Reg. No./Substance:
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10102-06-4/Uranyl Nitrate; 57-92-1/Streptomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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