| Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes. | |
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MedLine Citation:
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PMID: 3933364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventricular myocytes were isolated from adult rat hearts using the technique of Wittenberg and Robinson (Cell Tissue Res. 216: 231-251, 1981). These cells exhibited morphology, input resistance, time constant, and excitability expected for cells in intact cardiac tissue. Pairs of these cells were electronically coupled, and junctional conductance was unaffected by transjunctional potential or hyperpolarization of both cells. Brief exposure of cell pairs to medium equilibrated with 100% CO2 or containing 0.1 mM octanol quickly and reversibly decreased junctional conductance. We conclude that gap junctions between pairs of ventricular myocytes possess physiological properties like those of junctions in many other tissues. This preparation will be useful in evaluating drug action on junctional communication in heart. |
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Authors:
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R L White; D C Spray; A C Campos de Carvalho; B A Wittenberg; M V Bennett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 249 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1985-12-12 Completed Date: 1985-12-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: C447-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Dioxide / pharmacology Electric Wiring Electrophysiology / instrumentation Intercellular Junctions / drug effects, physiology* Male Myocardium / cytology* Octanols / pharmacology Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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HL-33655/HL/NHLBI NIH HHS; NS-16524/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Octanols; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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