Document Detail


Some effects of selenium deficiency on glutathione peroxidase (EC 1.11.1.9) activity and tissue pathology in rainbow trout (Salmo gairdneri).
MedLine Citation:
PMID:  3676160     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Two duplicate groups of rainbow trout (Salmo gairdneri; mean weight 27 g) were given diets of differing selenium content (deficient 0.025 mg Se/kg; supplemented 1.022 mg Se/kg) for 30 weeks. 2. There were no significant differences between treatments in weight gain but packed cell volume, liver vitamin E and liver and plasma Se concentrations were all significantly lower in the Se-deficient trout. 3. Ataxia occurred in about 10% of the Se-deficient trout and histopathologies were evident in nerve cord (damage to axon sheath) and liver (loss of integrity in endoplasmic reticulum and mitochondria with appearance of increased vesiculation). 4. Glutathione peroxidase (EC 1.11.1.9) activity was significantly reduced in liver and plasma of Se-deficient fish but there was no indication, from differential assay, of any non-Se-dependent glutathione peroxidase activity. Glutathione transferase (EC 2.5.1.18) activity was significantly increased in Se-deficient trout.
Authors:
J G Bell; B J Pirie; J W Adron; C B Cowey
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  55     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1987-12-28     Completed Date:  1987-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
Affiliation:
Institute of Marine Biochemistry, Aberdeen.
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MeSH Terms
Descriptor/Qualifier:
Animals
Glutathione Peroxidase / metabolism*
Liver / metabolism,  pathology*,  ultrastructure
Microscopy, Electron
Muscles / pathology*,  ultrastructure
Pyruvate Kinase / blood
Reference Values
Salmonidae / metabolism*
Selenium / blood,  deficiency*
Trout / metabolism*
Chemical
Reg. No./Substance:
7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase; EC 2.7.1.40/Pyruvate Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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