Document Detail

Some effects of orthovanadate on smooth muscle cells of guinea-pig taenia caeci.
MedLine Citation:
PMID:  3001789     Owner:  NLM     Status:  MEDLINE    
The effect of orthovanadate on the response caused by the beta-adrenergic receptor agonist isoprenaline and on the ATP response were investigated by measuring potential changes and changes in the contractile state of smooth muscle cells of guinea-pig taenia caeci at 35 degrees C using the sucrose-gap method. The contraction evoked by carbachol (10(-7) M) or potassium (15 mM) was not modified by orthovanadate (1.0 mM). The hyperpolarization evoked in smooth muscle cells by ATP (0.4 mM) was affected to some extent by orthovanadate (1.0 mM), but was not modified in the absence of extracellular calcium. The hyperpolarization caused by isoprenaline (3 X 10(-6) M), however, was inhibited completely both in the presence and absence of calcium. These results are consistent with the view that isoprenaline activates calcium extrusion from the smooth muscle cells, a process being electrogenic in nature.
A den Hertog; J Pielkenrood; J van den Akker
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  31     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1985  
Date Detail:
Created Date:  1986-02-14     Completed Date:  1986-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
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MeSH Terms
Carbachol / pharmacology
Cecum / cytology,  drug effects
Guinea Pigs
Isoproterenol / pharmacology
Muscle Relaxation / drug effects
Muscle, Smooth / cytology,  drug effects*
Potassium / pharmacology
Receptors, Adrenergic, beta / drug effects
Stimulation, Chemical
Vanadium / pharmacology*
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 0/Vanadates; 51-83-2/Carbachol; 7440-09-7/Potassium; 7440-62-2/Vanadium; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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