Document Detail

Some effects of desmethylimipramine and amitriptyline on the schedule-controlled behavior of pigeons and rats.
MedLine Citation:
PMID:  2636825     Owner:  NLM     Status:  MEDLINE    
The effects of desmethylimipramine and amitriptyline on schedule-controlled behavior of pigeons and rats were examined. Pigeons responded under either a multiple (mult) fixed-interval (FI) 600-sec, fixed-ratio (FR) 30-response schedule of food presentation or a mult FI 200-sec, FI 200-sec schedule, in which responding during one component was punished with electric shock. Rats responded under a mult FI 300-sec, FR 30-response schedule of food presentation. Under the mult FI, FR schedules, desmethylimipramine and amitriptyline decreased overall rates of FI and FR responding in both species. Overall rates of responding were decreased to similar extents under both the FI and FR components of the schedule. In the pigeon, but not in the rat, the effects of desmethylimipramine and amitriptyline on responding under the FI component of the mult FI, FR schedule depended on the control-rate of responding, i.e. desmethylimipramine and amitriptyline increased more or decreased less the low rates of FI responding at the beginning of the FI compared to the higher rates of FI responding at the end of the FI. In contrast, in the rat desmethylimipramine and amitriptyline did not differentially affect the low rates of responding at the beginning of the FI compared to the higher rates of responding at the end of the FI. Correspondingly, in the pigeon, but not in the rat, desmethylimipramine and amitriptyline decreased the fixed-interval quarter-life at relatively low doses. In the pigeon neither desmethylimipramine nor amitriptyline differentially affected the overall rate of punished as compared to unpunished responding.
R J Lamb; D E McMillan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  302     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-07-02     Completed Date:  1990-07-02     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  49-67     Citation Subset:  IM    
Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.
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MeSH Terms
Amitriptyline / pharmacology*
Conditioning, Operant / drug effects*
Desipramine / pharmacology*
Reinforcement (Psychology)
Reinforcement Schedule
Species Specificity
Grant Support
Reg. No./Substance:
50-47-5/Desipramine; 50-48-6/Amitriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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