Document Detail


Some effects of deoxycholate administration on the metabolism of cholesterol in man.
MedLine Citation:
PMID:  377936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypercholesterolemic subjects in a metabolic ward were kept under uniform dietary conditions until constant levels of serum cholesterol were observed. Oral dosage with deoxycholate (1.5 to 3 g daily for a period of 4 to 10 weeks) resulted in a marked reduction of serum cholesterol concentration. Studies with 14C-labeled cholesterol demonstrated that deoxycholate administration decreased absorption of cholesterol from the human intestinal tract. In these subjects, the turnover rate of serum cholesterol was more rapid during therapy with deoxycholate than during control periods. Deoxycholate appeared to influence the intestinal flora as assessed indirectly by analysis of the types of neutral sterols eliminated with the feces. Decreased synthesis of cholesterol during deoxycholate administration uas demonstrated in a study with 14C-mevalonate. It is concluded that deoxycholic acid can have an important role in the regulation of cholesterol metabolism in humans.
Authors:
H E Gallo-Torres; O N Miller; J G Hamilton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  32     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1363-75     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anticholesteremic Agents*
Cholestanol / metabolism
Cholestanols / metabolism
Cholesterol / biosynthesis,  blood,  metabolism*
Cholesterol Esters / blood
Deoxycholic Acid / pharmacology*,  physiology
Feces / analysis
Female
Humans
Hypercholesterolemia / metabolism*
Intestinal Absorption / drug effects
Intestines / microbiology
Male
Middle Aged
Sterols / metabolism
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholestanols; 0/Cholesterol Esters; 0/Sterols; 57-88-5/Cholesterol; 80-97-7/Cholestanol; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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