| Some characteristics of beta-naphthyl oligophosphates as allosteric effectors of human hemoglobin. | |
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MedLine Citation:
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PMID: 7106359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Fluorescent organic phosphates. beta-naphthyl oligophosphates, were found to interact with human hemoglobin, and to lower the oxygen affinity. The magnitude of the allosteric effect depended on the number of phosphoric groups in each compound. 2. In analogy with inositol hexaphosphate (IHP). beta-naphthyl tetraphosphate (beta-NapP4) was found to interact with oxyhemoglobin. Therefore, the spectral changes in oxyhemoglobin and carboxyhemoglobin induced by beta-NapP4 and IHP were compared. 3. The extent of spectral changes in oxyhemoglobin induced by beta-NapP4 was smaller than that induced by IHP, whereas the extent of spectral changes in carboxyhemoglobin induced by beta-NapP4 was about twice that by IHP. 4. These results indicate that there is a structural difference between oxyhemoglobin and carboxyhemoglobin. |
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Authors:
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K Horiuchi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of biochemistry Volume: 14 ISSN: 0020-711X ISO Abbreviation: Int. J. Biochem. Publication Date: 1982 |
Date Detail:
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Created Date: 1982-10-29 Completed Date: 1982-10-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0250365 Medline TA: Int J Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 601-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allosteric Regulation
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drug effects Carboxyhemoglobin / metabolism Chemical Phenomena Chemistry Humans Naphthols / blood, pharmacology* Organophosphorus Compounds / blood, pharmacology* Oxyhemoglobins / metabolism* Phytic Acid / pharmacology Protein Binding Spectrophotometry Stereoisomerism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Naphthols; 0/Organophosphorus Compounds; 0/Oxyhemoglobins; 83-86-3/Phytic Acid; 9061-29-4/Carboxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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