| Some biological properties of Pneumococcus type 37 and the chemistry of its capsular polysaccharide. | |
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MedLine Citation:
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PMID: 4399979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pneumococcus Type 37, like pneumococcus Type 3, is characterized by the production of large mucoid colonies on the surface of solid media and by its very large capsule. It differs from the highly virulent pneumococcus Type 3 in that it is only slightly virulent for mice and rats and is isolated infrequently from man. A study of the behavior of pneumococcus Type 37 in systems comparable to those used in the study of pneumococcus Type 3 and an examination of the chemical structure of the capsule of pneumococcus Type 37 are described. The capsular polysaccharide of pneumococcus Type 37 is a viscous, optically inactive polymer composed of 95% hexose. Glucose is obtained in 88% yield upon acid hydrolysis. Periodate oxidation studies and the behavior of the polysaccharide on acid hydrolysis suggest that the molecule consists of a core of repeating units of 1,3 glucosyl-glucose to which short chains of glucose are attached at frequent intervals. Isolation of a disaccharide, the properties of which are identical with those of sophorose (beta1 --> 2 glucosyl-glucose), and of a trisaccharide are described. A tentative structure for the capsular polysaccharide of pneumococcus Type 37 is proposed. |
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Authors:
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J C Knecht; G Schiffman; R Austrian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 132 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1970 Sep |
Date Detail:
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Created Date: 1972-03-17 Completed Date: 1972-03-17 Revised Date: 2010-09-13 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 475-87 Citation Subset: AIM; IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Glucose
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analysis Hexoses / analysis Monosaccharides / analysis Oligosaccharides / analysis Phagocytosis Polysaccharides, Bacterial / analysis* Streptococcus pneumoniae* / analysis, pathogenicity Virulence Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Hexoses; 0/Monosaccharides; 0/Oligosaccharides; 0/Polysaccharides, Bacterial; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1970 by The Rockefeller University Press Received Day: 27 Month: 4 Year: 1970 Print publication date: Day: 1 Month: 9 Year: 1970 Volume: 132 Issue: 3 First Page: 475 Last Page: 487 ID: 2138812 PubMed Id: 4399979 |
| SOME BIOLOGICAL PROPERTIES OF PNEUMOCOCCUS TYPE 37 AND THE CHEMISTRY OF ITS CAPSULAR POLYSACCHARIDE | |
| Judith C. Knecht | |
| Gerald Schiffman | |
| Robert Austrian | |
| From the John Herr Musser Department of Research Medicine, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 |
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