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Some biological properties of Pneumococcus type 37 and the chemistry of its capsular polysaccharide.
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MedLine Citation:
PMID:  4399979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pneumococcus Type 37, like pneumococcus Type 3, is characterized by the production of large mucoid colonies on the surface of solid media and by its very large capsule. It differs from the highly virulent pneumococcus Type 3 in that it is only slightly virulent for mice and rats and is isolated infrequently from man. A study of the behavior of pneumococcus Type 37 in systems comparable to those used in the study of pneumococcus Type 3 and an examination of the chemical structure of the capsule of pneumococcus Type 37 are described. The capsular polysaccharide of pneumococcus Type 37 is a viscous, optically inactive polymer composed of 95% hexose. Glucose is obtained in 88% yield upon acid hydrolysis. Periodate oxidation studies and the behavior of the polysaccharide on acid hydrolysis suggest that the molecule consists of a core of repeating units of 1,3 glucosyl-glucose to which short chains of glucose are attached at frequent intervals. Isolation of a disaccharide, the properties of which are identical with those of sophorose (beta1 --> 2 glucosyl-glucose), and of a trisaccharide are described. A tentative structure for the capsular polysaccharide of pneumococcus Type 37 is proposed.
Authors:
J C Knecht; G Schiffman; R Austrian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  132     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1970 Sep 
Date Detail:
Created Date:  1972-03-17     Completed Date:  1972-03-17     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  475-87     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Glucose / analysis
Hexoses / analysis
Monosaccharides / analysis
Oligosaccharides / analysis
Phagocytosis
Polysaccharides, Bacterial / analysis*
Streptococcus pneumoniae* / analysis,  pathogenicity
Virulence
Viscosity
Chemical
Reg. No./Substance:
0/Hexoses; 0/Monosaccharides; 0/Oligosaccharides; 0/Polysaccharides, Bacterial; 50-99-7/Glucose
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1970 by The Rockefeller University Press
Received Day: 27 Month: 4 Year: 1970
Print publication date: Day: 1 Month: 9 Year: 1970
Volume: 132 Issue: 3
First Page: 475 Last Page: 487
ID: 2138812
PubMed Id: 4399979

SOME BIOLOGICAL PROPERTIES OF PNEUMOCOCCUS TYPE 37 AND THE CHEMISTRY OF ITS CAPSULAR POLYSACCHARIDE
Judith C. Knecht
Gerald Schiffman
Robert Austrian
From the John Herr Musser Department of Research Medicine, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104


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