Document Detail

Some behavioral effects of histamine H1-, and H2-receptor agonists in rats.
MedLine Citation:
PMID:  493178     Owner:  NLM     Status:  MEDLINE    
2-Pyridylethylamine (2-PEA) and 4-methylhistamine (4-MeHI) when given intraventricularly at doses of 30 and 100 microgram had no discernible effect on spontaneous locomotor activity and did not visibly change gross behavior of rats. 4-MeHI(100 micrograms) injected to tranylcypromine-pretreated rats increased locomotor activity and induced head twitches. Locomotor activation was not antagonized by either cimetidine or metergoline but was prevented by alpha-methyl-p-tyrosine and haloperidol and reduced by phentolamine. 4-MeHI-, and histamine (HI)-induced head twitches were not antagonized by either cimetidine or metiamide but were completely abolished by metergoline and p-chlorophenylalanine. It is concluded that 4-MeHI--induced locomotor activation and both HI-, and 4-MeHI-induced head twitches are respectively catecholamine-, and serotonin-dependent phenomena. The behavioral effects of HI and HI H1-and H2-receptor agonists are discussed with regard to possible HI interactions with both catecholamine and serotonin systems in brain.
J Z Nowak; A Pilc
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Polish journal of pharmacology and pharmacy     Volume:  31     ISSN:  0301-0244     ISO Abbreviation:  Pol J Pharmacol Pharm     Publication Date:    1979 Mar-Apr
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0366561     Medline TA:  Pol J Pharmacol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  115-26     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal / drug effects*
Cimetidine / pharmacology
Drug Interactions
Ethylamines / pharmacology
Metergoline / pharmacology
Methylhistamines / pharmacology
Motor Activity / drug effects
Receptors, Histamine / drug effects*
Receptors, Histamine H1 / drug effects*
Receptors, Histamine H2 / drug effects*
Time Factors
Tranylcypromine / pharmacology
Reg. No./Substance:
0/Ethylamines; 0/Methylhistamines; 0/Receptors, Histamine; 0/Receptors, Histamine H1; 0/Receptors, Histamine H2; 155-09-9/Tranylcypromine; 17692-51-2/Metergoline; 51481-61-9/Cimetidine

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