Document Detail


Some aspects of clinical relevance in the maturation of respiratory control in infants.
MedLine Citation:
PMID:  18420716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two reflex mechanisms important for survival are discussed. Brain stem and cardiovascular mechanisms that are responsible for recovery from severe hypoxia (autoresuscitation) are important for survival in acutely hypoxic infants and adults. Failure of this mechanism may be important in sudden infant death syndrome (SIDS), because brain stem-mediated hypoxic gasping is essential for successful autoresuscitation and because SIDS infants appear to attempt to autoresuscitate just before death. A major function of another mechanism is to protect the airway from fluid aspiration. The various components of the laryngeal chemoreflex (LCR) change during maturation. The LCR is an important cause of prolonged apneic spells in infants. Consequently, it also may have a role in causing SIDS. Maturational changes and/or inadequacy of this reflex may be responsible for pulmonary aspiration and infectious pneumonia in both children and adults.
Authors:
Bradley T Thach
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-04-17
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-04     Completed Date:  2008-08-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1828-34     Citation Subset:  IM    
Affiliation:
Edward Mallinckrodt Department of Pediatrics, Washington Univ. School of Medicine, St. Louis, MO 63110, USA. thach@kids.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adult
Anoxia / complications,  physiopathology*
Apnea / complications,  physiopathology*
Chemoreceptor Cells / physiopathology
Deglutition
Humans
Infant
Infant, Newborn
Larynx / physiopathology
Lung / innervation,  physiopathology*
Pneumonia, Aspiration / physiopathology
Reflex*
Respiration*
Respiratory Center / physiopathology
Respiratory Mechanics
Respiratory Tract Infections / complications,  physiopathology
Sudden Infant Death / etiology*
Grant Support
ID/Acronym/Agency:
HD-10993/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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