| Somatropin in adults: new preparation. No benefit. | |
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MedLine Citation:
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PMID: 10848047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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(1) Growth hormone deficiency in adults is a poorly defined disease, and its impact in terms of morbidity and mortality is not known. (2) The assessment files on the three somatropin ranges are based on results for nearly 600 adult patients included in placebo-controlled trials. (3) While clinical trials are relatively numerous, their quality is mediocre. Only methodological trickery enabled the authors to elicit significant results using surrogate end points; no benefit of somatropin on tangible clinical criteria has been proven. (4) At the beginning of treatment somatropin frequently has adverse effects linked to water and sodium retention; the risk of severe adverse effects has not been ruled out (diabetogenic or carcinogenic effects). (5) Treatment necessitates chronic daily injections. |
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Authors:
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prescrire international Volume: 7 ISSN: 1167-7422 ISO Abbreviation: Prescrire Int Publication Date: 1998 Dec |
Date Detail:
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Created Date: 2000-05-04 Completed Date: 2000-05-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9439295 Medline TA: Prescrire Int Country: FRANCE |
Other Details:
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Languages: eng Pagination: 172-4 Citation Subset: T |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Clinical Trials as Topic France Human Growth Hormone* / administration & dosage, adverse effects, deficiency, therapeutic use Humans Hypopituitarism / diagnosis, drug therapy* |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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