| Somatostatin's ability to inhibit gastric acid is not prostaglandin-mediated in the dog. | |
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MedLine Citation:
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PMID: 2874043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of prostaglandins in the effect of somatostatin to inhibit cholinergically stimulated gastric acid output was examined in gastric fistula dogs. Methacholine stimulation of gastric acid output to a maximum of 810 +/- 423 mu eq of [H+] per 15 min was inhibited by 10 nM somatostatin to the same extent either in the presence and/or the absence of indomethacin. In contrast, histamine-induced acid secretion was stimulated weakly by 10 nM somatostatin. Our data do not support a role for prostaglandins in somatostatin's action to inhibit cholinergically stimulated acid secretion. |
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Authors:
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J G Gerber; M Hughes; N A Payne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 125 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-09-25 Completed Date: 1986-09-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 449-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Drug Interactions Gastric Acid / secretion* Histamine / pharmacology Indomethacin / pharmacology Methacholine Compounds / pharmacology Prostaglandins / physiology* Somatostatin / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AM31607/AM/NIADDK NIH HHS; HL21308/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methacholine Compounds; 0/Prostaglandins; 51-45-6/Histamine; 51110-01-1/Somatostatin; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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