Document Detail


Somatostatin signal transduction in thyroid parafollicular C cells.
MedLine Citation:
PMID:  15481818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of somatostatin (SRIF) through its receptors (SSTRs) has been explored in many tissues, and here we discuss the role of the SRIF-SSTR system in human parafollicular C cells, reporting recent data on the effects of selective SSTR agonists on parafollicular C cells, that suggest new therapeutic approaches for medical treatment of medullary thyroid carcinoma. Moreover, the possible pathways involved in SRIF signalling in parafollicular C cells are discussed.
Authors:
M C Zatelli; E C degli Uberti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  27     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-14     Completed Date:  2004-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  168-70     Citation Subset:  IM    
Affiliation:
Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Receptors, Somatostatin / agonists,  antagonists & inhibitors,  physiology
Signal Transduction / drug effects,  physiology*
Somatostatin / pharmacology,  physiology*
Thyroid Gland / cytology,  drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Receptors, Somatostatin; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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