| Somatostatin receptors in normal and tumoral tissue. | |
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MedLine Citation:
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PMID: 2900198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Somatostatin receptors have been visualized with autoradiography and characterised biochemically in various somatostatin target tissues, such as brain, pituitary, pancreas and gastrointestinal tract, where they are likely to mediate the somatostatin actions. With the same methods, somatostatin receptors have been detected also in tumors originating from somatostatin target tissues: high receptor incidence is found in GH-producing pituitary adenomas as well as in some hormone-producing gastrointestinal tumors. These tumors are often highly responsive to somatostatin analogs in vivo. Among brain tumors, meningiomas usually contain a high density of receptors, suggesting a novel function for somatostatin in the human meninges. Among other human tumors tested, prostate, ovarian and endometrial carcinomas were free of receptors whereas 3 out of 39 mammary tumors contained somatostatin receptors. |
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Authors:
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J C Reubi; S W Lamberts; R Maurer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone research Volume: 29 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-09-16 Completed Date: 1988-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 65-9 Citation Subset: IM |
Affiliation:
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Sandoz Research Institute, Berne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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physiopathology* Animals Gastrointestinal Neoplasms / physiopathology* Humans Neoplasms / physiopathology Pituitary Neoplasms / physiopathology* Receptors, Neurotransmitter / physiology* Receptors, Somatostatin Somatostatin / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Neurotransmitter; 0/Receptors, Somatostatin; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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