Document Detail

Somatostatin: a potent inhibitor of ACTH-hypersecretion in adrenal insufficiency.
MedLine Citation:
PMID:  1256005     Owner:  NLM     Status:  MEDLINE    
Somatostatin (250 mug as a bolus i.v. and 250 mug as a 1-hr infusion) was administered to 5 patients with adrenal insufficiency of different origin. In each patient a sustained, progressive fall in plasma ACTH was observed during the infusion period. The mean maximal reduction in plasma ACTH was 43.8 +/- 5.9%. After cessation of the somatostatin infusion there was a rise of plasma ACTH to starting levels within 1/2 hour. These findings suggest that somatostatin is a potent inhibitor of ACTH secretion, however, only in a condition in which glucocorticoids are lacking.
H L Fehm; K H Voigt; R Lang; K E Beinert; S Raptis; E F Pfeiffer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  54     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-05-20     Completed Date:  1976-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  173-5     Citation Subset:  IM    
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MeSH Terms
Addison Disease / metabolism
Adrenal Insufficiency / metabolism*
Cushing Syndrome / metabolism
Pituitary Neoplasms / secretion
Somatostatin / pharmacology*
Reg. No./Substance:

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