| Somatostatin inhibits rapid centrosomal separation and cell proliferation induced by epidermal growth factor. | |
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MedLine Citation:
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PMID: 6126353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of endogenous growth inhibitors in the regulation of cell proliferation is unclear. Although there are numerous studies on the stimulatory effect of peptide hormones such as insulin, the somatomedins and epidermal growth factor (EGF) on cell proliferation, little is known about the existence of hormones that might exert an antiproliferative effect on cells. Somatostatin (SS), a cyclic tetradecapeptide hormone that is widely distributed in the body, exerts an inhibitory effect on numerous cellular processes. We observed that SS at concentrations of 10(-8) - 10(13M), inhibited EGF-induced centrosomal separation, which recent evidence suggests is necessary for DNA synthesis in response to EGF. This SS effect was associated with inhibition of DNA synthesis and cell replication induced by EGF in gerbil fibroma and HeLa cells. Inhibition of centrosomal separation and the consequent antiproliferative effect of SS may represent a biologically significant action of this ubiquitous hormone. |
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Authors:
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R N Mascardo; P Sherline |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrinology Volume: 111 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1982-12-03 Completed Date: 1982-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1394-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / drug effects* Cell Line DNA / biosynthesis Epidermal Growth Factor / pharmacology* Fibroma Gerbillinae Hela Cells Humans Interphase / drug effects Somatostatin / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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GM-22497/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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51110-01-1/Somatostatin; 62229-50-9/Epidermal Growth Factor; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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