Document Detail


Somatostatin inhibits gastric acid secretion after gastric mucosal prostaglandin synthesis inhibition by indomethacin in man.
MedLine Citation:
PMID:  2866148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effect of indomethacin, 200 + 200 mg administered per os over 24 hours, on the prostaglandin E2 generative capacity of gastric mucosal tissue was determined in healthy male volunteers. The effect of prostaglandin synthesis inhibition on somatostatin induced suppression of food-stimulated acid secretion was tested. Peptone meal stimulated acid secretion was quantified in five healthy volunteers by intragastric titration with and without indomethacin pretreatment. Somatostatin doses of 200, 400, and 800 pmol/kg/h each significantly inhibited the peptone stimulated acid output. Indomethacin treatment, resulting in 90% inhibition of prostaglandin E2 synthesis, did not affect glucose- or peptone-stimulated acid output or modify the inhibitory action of somatostatin. Clinically, acid inhibition by somatostatin has been used to treat bleeding peptic ulcers. Ulcer haemorrhage may be preceded by an excessive use of drugs that inhibit prostaglandin synthesis such as aspirin or other non-steroidal anti-inflammatory agents. Recent observations in the rat indicate that prostaglandins mediate the inhibitory action of somatostatin on gastric acid secretion. The present results suggest that prostaglandins are not required for inhibition of gastric acid secretion by somatostatin in man.
Authors:
M H Mogard; V Maxwell; T Kovacs; G Van Deventer; J D Elashoff; T Yamada; G L Kauffman; J H Walsh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gut     Volume:  26     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-01-08     Completed Date:  1986-01-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1189-91     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Depression, Chemical
Dinoprostone
Gastric Acid / secretion*
Gastric Mucosa / drug effects*
Humans
Indomethacin / pharmacology*
Male
Prostaglandins E / biosynthesis*
Somatostatin / pharmacology*
Grant Support
ID/Acronym/Agency:
AM 08354/AM/NIADDK NIH HHS; AM 17294/AM/NIADDK NIH HHS; AM 17328/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins E; 363-24-6/Dinoprostone; 51110-01-1/Somatostatin; 53-86-1/Indomethacin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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