Document Detail

Somatostatin inhibition of intrinsic factor secretion from isolated guinea pig gastric glands.
MedLine Citation:
PMID:  2883725     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to examine the direct effect of somatostatin on histamine- and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10(-11) M to 10(-6) M) on half-maximal doses of histamine (10(-6) M), pentagastrin (10(-6) M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10(-10) M to 10(-6) M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin (10(-6) M) inhibited histamine-stimulated (10(-6) M) IF release by 69.9 +/- 7.2% and the combination of histamine (10(-6) M) and pentagastrin (10(-6) M) by 64.2 +/- 9.1%. This is the first in vitro demonstration that somatostatin inhibits IF release.
M Oddsdottir; G H Ballantyne; T E Adrian; M J Zdon; K A Zucker; I M Modlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  22     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-11     Completed Date:  1987-06-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
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MeSH Terms
Dithiothreitol / pharmacology
Gastrins / secretion
Guinea Pigs
Histamine / pharmacology
Intrinsic Factor / secretion*
Parietal Cells, Gastric / drug effects*
Pentagastrin / pharmacology
Secretory Rate / drug effects
Somatostatin / pharmacology*
Reg. No./Substance:
0/Gastrins; 3483-12-3/Dithiothreitol; 51-45-6/Histamine; 51110-01-1/Somatostatin; 5534-95-2/Pentagastrin; 9008-12-2/Intrinsic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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