| Somatostatin inhibition of intrinsic factor secretion from isolated guinea pig gastric glands. | |
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MedLine Citation:
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PMID: 2883725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of our study was to examine the direct effect of somatostatin on histamine- and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10(-11) M to 10(-6) M) on half-maximal doses of histamine (10(-6) M), pentagastrin (10(-6) M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10(-10) M to 10(-6) M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin (10(-6) M) inhibited histamine-stimulated (10(-6) M) IF release by 69.9 +/- 7.2% and the combination of histamine (10(-6) M) and pentagastrin (10(-6) M) by 64.2 +/- 9.1%. This is the first in vitro demonstration that somatostatin inhibits IF release. |
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Authors:
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M Oddsdottir; G H Ballantyne; T E Adrian; M J Zdon; K A Zucker; I M Modlin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 22 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-06-11 Completed Date: 1987-06-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 233-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dithiothreitol / pharmacology Gastrins / secretion Guinea Pigs Histamine / pharmacology Intrinsic Factor / secretion* Parietal Cells, Gastric / drug effects* Pentagastrin / pharmacology Secretory Rate / drug effects Somatostatin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 3483-12-3/Dithiothreitol; 51-45-6/Histamine; 51110-01-1/Somatostatin; 5534-95-2/Pentagastrin; 9008-12-2/Intrinsic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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