Document Detail

Somatostatin in the cerebrospinal fluid of schizophrenic patients before and after neuroleptic drug treatment.
MedLine Citation:
PMID:  8094631     Owner:  NLM     Status:  MEDLINE    
A radioimmunoassay procedure was used to determine levels of somatostatin-like immunoreactivity in cerebrospinal fluid obtained from 9 schizophrenic patients, 7 patients with other psychiatric disorders, and 10 nonpsychiatric surgical controls. There were no significant differences in mean somatostatin baseline levels between the schizophrenic, nonschizophrenic, and surgical patients. The concentration remained almost unaltered after 4 weeks of zuclopenthixol treatment in the schizophrenia group and following various neuroleptic, antidepressant, and anxiolytic medications in the nonschizophrenic patients despite a significant decrease of overt psychopathology assessed by the Brief Psychiatric Rating Scale.
L Heikkilä
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  8     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-24     Completed Date:  1993-03-24     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Uusikaupunki Hospital, Finland.
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MeSH Terms
Borderline Personality Disorder / cerebrospinal fluid,  drug therapy
Chronic Disease
Clopenthixol / therapeutic use*
Drug Therapy, Combination
Lorazepam / therapeutic use
Middle Aged
Neurotic Disorders / cerebrospinal fluid,  drug therapy
Psychiatric Status Rating Scales
Psychotropic Drugs / therapeutic use
Schizophrenia / cerebrospinal fluid,  drug therapy*
Schizophrenic Psychology*
Somatostatin / cerebrospinal fluid*
Reg. No./Substance:
0/Psychotropic Drugs; 51110-01-1/Somatostatin; 846-49-1/Lorazepam; 982-24-1/Clopenthixol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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