| Somatostatin-gastrin interactions in the rat stomach. | |
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MedLine Citation:
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PMID: 2897707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low concentrations of somatostatin and gastrin within or slightly above the range of physiologically circulating levels were perfused in the isolated, vascularly perfused rat stomach preparation. Somatostatin at 10 and 50 pg/ml significantly inhibited acetylcholine-stimulated gastrin secretion by 26% and 45%, respectively, whereas perfusion of 50 and 500 pg/ml exogenous gastrin did not modify gastric somatostatin secretion. Perfusion of somatostatin-antiserum significantly increased gastrin release by 235%. It is concluded that (1) somatostatin is a powerful inhibitor of the gastrin cell under in vitro conditions; the data are in accordance with a concept that endogenous somatostatin could act as a true hormone; (2) the secretory activity of the somatostatin cell is not significantly affected by circulating gastrin. |
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Authors:
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H Koop; E Bothe; R Eissele; J Dionysius; R Arnold |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie Volume: 188 ISSN: 0300-9130 ISO Abbreviation: Res Exp Med (Berl) Publication Date: 1988 |
Date Detail:
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Created Date: 1988-06-27 Completed Date: 1988-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0324736 Medline TA: Res Exp Med (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 115-21 Citation Subset: IM |
Affiliation:
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Dept. of Medicine, Philipps University, Marburg, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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antagonists & inhibitors,
pharmacology Animals Gastric Mucosa / drug effects, secretion* Gastrins / pharmacology*, secretion Kinetics Male Perfusion Rats Rats, Inbred Strains Somatostatin / pharmacology*, secretion |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 51-84-3/Acetylcholine; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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