Document Detail

Somatostatin- and factor XIIIa-immunoreactive cells in psoriasis during clobetasol propionate and calciprotriol treatment.
MedLine Citation:
PMID:  10086858     Owner:  NLM     Status:  MEDLINE    
This study describes the changes in number and distribution of somatostatin- and factor XIIIa-immunoreactive dendritic cells in the epidermis and dermis of psoriatic lesional skin during topical treatment with clobetasol propionate or calcipotriol. Immunohistochemical analysis showed that the number of each cell type was increased in lesional skin as compared to normal skin. Investigation of serial biopsies from psoriasis lesions revealed a significant reduction in the number of somatostatin- and factor XIIIa-positive dendritic cells during the treatments. The reduction rate of the somatostatin-positive cells differed between the two groups and closely paralleled the healing process induced by the two treatments. These findings and the fact that somatostatin has been used in several studies as treatment for psoriasis may indicate that the somatostatin-positive cells are specifically involved in the healing process of psoriasis. The reduction of the factor XIIIa-positive cells was associated with the healing process as a whole, but showed no relation to either treatment.
T Talme; M Schultzberg; K G Sundqvist; J A Marcusson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  79     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
Department of Dermatology, Huddinge University Hospital, Sweden.
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MeSH Terms
Calcitriol / analogs & derivatives*,  therapeutic use
Clobetasol / therapeutic use*
Dendritic Cells / chemistry,  cytology,  drug effects
Dermatologic Agents / therapeutic use
Fluorescent Antibody Technique, Indirect
Glucocorticoids / therapeutic use
Middle Aged
Psoriasis / drug therapy*,  pathology
Skin / chemistry,  cytology,  pathology
Somatostatin / analysis,  drug effects*
Transglutaminases / analysis,  drug effects*
Reg. No./Substance:
0/Dermatologic Agents; 0/Glucocorticoids; 112965-21-6/calcipotriene; 25122-41-2/Clobetasol; 32222-06-3/Calcitriol; 51110-01-1/Somatostatin; EC

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