| Somatostatin cells in the oxyntic mucosa of hypo- or hypergastrinemic rats. | |
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MedLine Citation:
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PMID: 1352909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present report describes the long-term effects of antrectomy, antrum exclusion, portacaval shunt, omeprazole treatment, or the combination of omeprazole treatment and portacaval shunt on the number and density of somatostatin cells in the oxyntic mucosa of the rat. Antrectomy, which is associated with hypogastrinemia, raised the number and density of the somatostatin cells, whereas antrum exclusion and omeprazole treatment, which are associated with hypergastrinemia, reduced the number and density of the somatostatin cells. Portacaval shunt, which is associated with hypogastrinemia, increased both the number and the density. Omeprazole treatment of portacaval--shunted rats suppressed or even reversed the somatostatin cell hyperplasia after portacaval shunt alone. From these findings it is unlikely that gastrin stimulates the proliferation of somatostatin cells in the oxyntic mucosa. In fact, there seems to be an inverse relationship between the serum gastrin concentration and the somatostatin cell number. |
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Authors:
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D Chen; A Uribe; R Håkanson; F Sundler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 27 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-08-14 Completed Date: 1992-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 479-82 Citation Subset: IM |
Affiliation:
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Dept. of Pharmacology, University of Lund, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gastrins / blood*, physiology Male Omeprazole / pharmacology Parietal Cells, Gastric / cytology, drug effects, secretion* Pyloric Antrum / surgery Rats Rats, Inbred Strains Somatostatin / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 51110-01-1/Somatostatin; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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