| Somatostatin antagonism prevents elemental diet-induced intestinal atrophy in the rat. | |
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MedLine Citation:
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PMID: 11575454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Somatostatin is a peptide with known antiproliferative effects on the intestine. The aim of the present work was to determine whether somatostatin (SST) antagonism reduces elemental diet-induced intestinal atrophy in the rat. Male Wistar rats were fed a standard diet and treated for seven days with either continuous infusion of saline or low and high doses of a putative somatostatin antagonist; another group was given a SST antagonist in a pulsatile high dose. All these groups received an elemental diet to induce gut mucosa atrophy. Rats were killed and samples were obtained for morphometric and proliferative measurements of the intestine and for SST and insulin-like growth factor-1 (IGF-1) level determination. The elemental diet decreased mucosal length and proliferation. Pulsatile administration of SST antagonist improved or prevented both effects, whereas continuous SST antagonist delivery prevented decreased crypt proliferation induced by the elemental diet. Somatostatin plasma levels were lowest in rats receiving pulsatile administration of SST antagonist. In conclusion, somatostatin antagonism increases proliferation in the intestinal mucosa, improving elemental diet-induced intestinal atrophy; however, morphological growth is not affected. |
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Authors:
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I A Gómez de Segura; T Castell; I Vázquez; A Mata; E De Miguel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 46 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-28 Completed Date: 2001-10-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1985-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Experimental Surgery, La Paz University Hospital, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Atrophy Cell Division Food, Formulated Insulin-Like Growth Factor I / analysis, physiology Intestinal Mucosa / pathology*, physiopathology Male Rats Rats, Wistar Receptors, Somatostatin / antagonists & inhibitors* Somatostatin / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Somatostatin; 51110-01-1/Somatostatin; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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