Document Detail

Somatostatin and analogs lack splanchnic vasoconstrictive effects in anesthetized pigs.
MedLine Citation:
PMID:  2890795     Owner:  NLM     Status:  MEDLINE    
Due to an apparently selective vasoconstrictive effect on the splanchnic circulation, somatostatin (SRIF) has been advocated for the treatment of variceal hemorrhage. The present study was designed to compare and contrast the systemic and splanchnic hemodynamic effects of SRIF and two of its long-acting analogs (SMS 201,995 and L 363,568) with those of Pitressin. Anesthetized pigs were subjected to laparotomy for placement of an electromagnetic flowmeter on the main trunk of the superior mesenteric artery (SMA). Systemic hemodynamic parameters of arterial blood pressure and cardiac output were monitored with thermodilution catheters. Portal venous blood was collected for measurement of plasma levels of SMS 201,995 and L 363,568 and for determination of gastrin levels during infusion of the latter analog. Experimental drugs were administered via an aortic cannula in a range (5-10 mg/kg bolus and 5-10 mg/kg/min continuous infusion) of dosages. At the higher dosages, SRIF, SMS 201,995, and L 363,568 decreased SMA blood flow (mean% +/- SD) 5.6 +/- 2.2, 1.6 +/- 4.4, and 8.0 +/- 3.8 after 10 min. None of the values achieved significance when compared to variation in baseline determinations. Pitressin (0.25 units, intravenously) produced a consistent and highly significant (P less than 0.001) reduction-in SMA flow after 5 min. Pharmacologic levels of SMS 201,995 and L 363,568 were reliably achieved in portal blood and the latter produced significant reduction (P less than 0.05) in portal venous levels of gastrin. SRIF and its long-acting analogs produced no significant splanchnic nor systemic hemodynamic effects in this model.
R P Cambria; R Neville; G H Ballantyne; M J Zdon; K A Zucker; T E Adrian; I M Modlin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  43     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-21     Completed Date:  1987-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  452-9     Citation Subset:  IM    
Surgical Service, VA Medical Center, West Haven, Connecticut.
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MeSH Terms
Hemodynamics / drug effects
Peptides, Cyclic / pharmacology*
Somatostatin / analogs & derivatives*,  pharmacology*
Splanchnic Circulation / drug effects*
Vasoconstrictor Agents / pharmacology*
Vasopressins / pharmacology
Reg. No./Substance:
0/Peptides, Cyclic; 0/Vasoconstrictor Agents; 11000-17-2/Vasopressins; 51110-01-1/Somatostatin; 81377-02-8/seglitide; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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