Document Detail

Somatosensory profiling of intra-oral capsaicin and menthol in healthy subjects.
MedLine Citation:
PMID:  23331421     Owner:  NLM     Status:  MEDLINE    
This study was designed to investigate the effect of surrogate orofacial pain models on the quantitative sensory testing (QST) profile in healthy participants. Capsaicin, menthol, or saline (control) were applied topically onto the gingiva of 15 healthy subjects for 15 min. During application, the subjects rated pain intensity on a score of 0-10, on an electronic visual analog scale (VAS). A standardized intra-oral QST protocol was performed before and immediately after application. Data obtained before and after application were compared using rank-sum tests, and QST profiles were made after Z-transformation. Application of capsaicin caused moderate levels of pain (VAS(peak)  = 6.0 ± 0.7), and application of menthol produced mild levels of pain (VAS(peak)  = 1.8 ± 0.6). Capsaicin induced hypersensitivity to warmth, heat pain and cold pain and hyposensitivity to mechanical stimuli. Menthol induced hypersensitivity to cold and warmth. Saline caused hypersensitivity to heat pain and hyposensitivity to mechanical stimuli. However, somatosensory profiles from Z-scores demonstrated sensory gains regarding warmth detection and heat pain only after application of capsaicin. In conclusion, a standardized battery of QST showed somatosensory changes after application of capsaicin, menthol and saline to the gingiva. However, the Z-score-based profiles may only reflect the most prominent somatosensory changes and thus represent a conservative approach for evaluation of data.
Shengyi Lu; Lene Baad-Hansen; Thomas List; Zhenting Zhang; Peter Svensson
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  European journal of oral sciences     Volume:  121     ISSN:  1600-0722     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-07-16     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  D; IM    
Copyright Information:
© 2013 Eur J Oral Sci.
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MeSH Terms
Administration, Topical
Analysis of Variance
Capsaicin / pharmacology*
Cross-Over Studies
Double-Blind Method
Facial Pain / chemically induced*
Gingiva / drug effects*
Menthol / pharmacology*
Models, Biological
Pain Measurement / methods
Pain Threshold / drug effects*
Statistics, Nonparametric
Grant Support
Reg. No./Substance:
1490-04-6/Menthol; S07O44R1ZM/Capsaicin

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