Document Detail

Somatosensory evoked potentials in very preterm infants in relation to L-thyroxine supplementation.
MedLine Citation:
PMID:  9565416     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effect of L-thyroxine supplementation on neurologic maturation in very preterm infants with transient hypothyroxinemia. DESIGN: Randomized, double-blind, placebo-controlled, L-thyroxine supplementation trial. SETTING: Level III neonatal intensive care unit. SUBJECTS: A total of 200 infants <30 weeks' gestational age. INTERVENTION: Subjects were randomly assigned to receive L-thyroxine (8 microg/kg birth weight per day) or a placebo during the first 6 weeks of life. METHODS: Median nerve somatosensory evoked potentials were recorded, measuring cortical N1 peak latency at 2 weeks of age, at term, and at 6 months (corrected) age. RESULTS: Cortical N1 peak latency was not decreased significantly in the L-thyroxine group compared with the placebo group throughout the study period. CONCLUSION: L-Thyroxine supplementation during the first 6 weeks of life did not decrease cortical N1 peak latency in infants of <30 weeks' gestational age.
B J Smit; J H Kok; L S de Vries; A G van Wassenaer; F W Dekker; B W Ongerboer de Visser
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  101     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-05-20     Completed Date:  1998-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  865-9     Citation Subset:  AIM; IM    
Department of Neonatology, Emma Children's Hospital AMC, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Double-Blind Method
Evoked Potentials, Somatosensory / drug effects*
Infant, Newborn
Infant, Premature / blood,  physiology*
Thyroxine / blood,  pharmacology*,  therapeutic use*
Reg. No./Substance:

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