Document Detail

Somatosensory evoked potentials in very preterm infants.
MedLine Citation:
PMID:  10802462     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Cross-sectional and longitudinal reference values of cortical N(1) peak latency of the median nerve SEP in very preterm infants. METHODS: In infants in a placebo control group within an L-thyroxine supplementation trial, born at less than 30 weeks' gestation, cortical N(1) peak latency was measured at 2 weeks, at term and at 6 months corrected age. Cross-sectional N(1) latency values obtained in 50 infants and complete series of longitudinal values obtained in 15 infants were analyzed in relation to postmenstrual age (PMA). RESULTS: Mean N(1) latency decreased from 66 ms at 2 weeks to 38 ms at term and 20 ms at 6 months corrected age. Possible confounding factors did not have any significant effect on N(1) latency at 2 weeks or at term age except cranial ultrasound abnormalities at 2 weeks of age. CONCLUSIONS: Longitudinal N(1) latency values were consistent with cross-sectional N(1) latency values. The observed N(1) latency at term and at 6 months corrected age suggest that extrauterine maturation of the somatosensory pathway in infants born at less than 30 weeks' gestation is delayed by extrauterine life.
B J Smit; B W Ongerboer de Visser; L S de Vries; F W Dekker; J H Kok
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  111     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-14     Completed Date:  2000-07-14     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  901-8     Citation Subset:  IM    
Department of Neonatology, Emma Children's Hospital Academic Medical Center, University of Amsterdam, H3N-148, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
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MeSH Terms
Cross-Sectional Studies
Evoked Potentials, Somatosensory / drug effects,  physiology*
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Longitudinal Studies
Median Nerve / physiology*
Reaction Time
Reference Values
Thyroxine / therapeutic use*
Reg. No./Substance:
0/Placebos; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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