| Somatosensory evoked potentials for closed-loop control of anaesthetic depth using propofol in the urethane-anaesthetized rat. | |
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MedLine Citation:
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PMID: 11103186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary somatosensory cortical mass responses have been shown to exhibit dose-dependent changes in latency when general anaesthetics are administered. Here we describe a system in which the latency of evoked responses was measured automatically in real time in five animals. Latency changes were used to operate a closed-loop control of propofol delivery by intravenous infusion. The system attempted to induce and maintain a 1 ms increase in evoked response latency; this was reversed when infusion was discontinued. Allowing for the rapid and large biological fluctuations in the evoked response, this was achieved successfully. The system maintained a mean increase in latency of 1.27 (SD 0.42) ms. The mean statistical dispersion index of data obtained during the controlled period was 1.23 (0.3); in an ideal controllable system it approximates to 1. Such a system may provide a means for the automatic delivery of anaesthetics. |
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Authors:
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A Angel; R H Arnott; D A Linkens; C H Ting |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 85 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-12-07 Completed Date: 2000-12-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 431-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Science, University of Sheffield, Western Bank, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Closed-Circuit* Anesthesia, Intravenous / methods* Anesthetics, Intravenous / administration & dosage* Animals Automatic Data Processing Dose-Response Relationship, Drug Drug Delivery Systems Evoked Potentials, Somatosensory / drug effects* Female Infusions, Intravenous Propofol / administration & dosage* Rats Rats, Wistar Reaction Time / drug effects* Urethane |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 2078-54-8/Propofol; 51-79-6/Urethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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