Document Detail

Somatosensory evoked potentials for closed-loop control of anaesthetic depth using propofol in the urethane-anaesthetized rat.
MedLine Citation:
PMID:  11103186     Owner:  NLM     Status:  MEDLINE    
Primary somatosensory cortical mass responses have been shown to exhibit dose-dependent changes in latency when general anaesthetics are administered. Here we describe a system in which the latency of evoked responses was measured automatically in real time in five animals. Latency changes were used to operate a closed-loop control of propofol delivery by intravenous infusion. The system attempted to induce and maintain a 1 ms increase in evoked response latency; this was reversed when infusion was discontinued. Allowing for the rapid and large biological fluctuations in the evoked response, this was achieved successfully. The system maintained a mean increase in latency of 1.27 (SD 0.42) ms. The mean statistical dispersion index of data obtained during the controlled period was 1.23 (0.3); in an ideal controllable system it approximates to 1. Such a system may provide a means for the automatic delivery of anaesthetics.
A Angel; R H Arnott; D A Linkens; C H Ting
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  85     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-07     Completed Date:  2000-12-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  431-9     Citation Subset:  IM    
Department of Biomedical Science, University of Sheffield, Western Bank, UK.
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MeSH Terms
Anesthesia, Closed-Circuit*
Anesthesia, Intravenous / methods*
Anesthetics, Intravenous / administration & dosage*
Automatic Data Processing
Dose-Response Relationship, Drug
Drug Delivery Systems
Evoked Potentials, Somatosensory / drug effects*
Infusions, Intravenous
Propofol / administration & dosage*
Rats, Wistar
Reaction Time / drug effects*
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol; 51-79-6/Urethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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