Document Detail

Somatosensory evoked potential recovery in myotonic dystrophy.
MedLine Citation:
PMID:  11336894     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate recovery functions of the sensory cortex using somatosensory evoked potentials (SEPs) elicited by paired stimuli of the median nerve in patients with myotonic dystrophy (MD). SUBJECTS/METHODS: Twelve MD patients were enrolled in the present investigation. Five patients with facioscapulohumeral muscular dystrophy (FSH) and 12 healthy volunteers were studied as control groups. SEP was recorded from the hand sensory area contralateral to the median nerve stimulated at the wrist. Single pulse or paired-pulse stimuli at various interstimulus intervals (ISIs) (10, 20, 40, 60, 80, 100, 150, 200 and 300 ms) were given. Recovery functions of N9, N20onset-N20peak, N20-P25 and P25-N33 components were studied. RESULTS: Conventional SEPs to a single stimulus were normal in the latency and amplitude in all the patients. Recovery functions of both N9 and N20o-N20p components were normal in the patients. In contrast, in MD patients, disinhibited or hyperexcitable recovery pattern was observed in recovery curves of the N20-P25 or P25-N33 components, whereas those were normal in FSH patients. CONCLUSIONS: Disinhibited cortical excitability (or hyperexcitability) is present in the sensory cortex in patients with myotonic dystrophy. This may reflect cortical pathology or functional alteration of the sensory cortex in MD.
H Mochizuki; R Hanajima; H Kowa; Y Motoyoshi; H Ashida; K Kamakura; K Motoyoshi; Y Ugawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  112     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-06-28     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  793-9     Citation Subset:  IM    
Department of Neurology, National Shimoshizu Hospital, Shikawatashi 934-5, Yotsukaido, 284-0003, Chiba, Japan.
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MeSH Terms
Age Factors
Analysis of Variance
Evoked Potentials, Somatosensory / physiology*
Hand / innervation
Magnetic Resonance Imaging
Median Nerve / physiology,  physiopathology*
Middle Aged
Muscular Dystrophy, Facioscapulohumeral / physiopathology*
Myotonic Dystrophy / pathology,  physiopathology*
Reaction Time
Reference Values
Somatosensory Cortex / physiology,  physiopathology

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