Document Detail

Somatosensory-evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia.
MedLine Citation:
PMID:  18406202     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patients must remain immobile for magnetoencephalography (MEG) and MRI recordings to allow precise localization of brain function for pre-surgical functional mapping. In young children with epilepsy, this is accomplished with recordings during sleep or with anesthesia. This paper demonstrates that MEG can detect, characterize and localize somatosensory-evoked fields (SEF) in infants younger than 4 years of age with or without total intravenous anesthesia (TIVA). METHODS: We investigated the latency, amplitude, residual error (RE) and location of the N20m of the SEF in 26 infants (mean age=2.6 years). Seventeen patients underwent TIVA and 9 patients were tested while asleep, without TIVA. RESULTS: MEG detected 44 reliable SEFs (77%) in 52 median nerve stimulations. We found 27 reliable SEFs (79%) with TIVA and 13 reliable SEFs (72%) without TIVA. TIVA effects included longer latencies (p<0.001) and lower RE (p<0.05) compared to those without TIVA. Older patients and larger head circumferences also showed significantly shorter latencies (p<0.01). CONCLUSIONS: TIVA resulted in reliable SEFs with lower RE and longer latencies. SIGNIFICANCE: MEG can detect reliable SEFs in infants younger than 4 years old. When infants require TIVA for MEG and MRI acquisition, SEFs can still be reliably observed.
Eduard Bercovici; Elizabeth W Pang; Rohit Sharma; Ismail S Mohamed; Katsumi Imai; Ayataka Fujimoto; Ayako Ochi; Amrita Viljoen; Bill Chu; Stephanie Holowka; Sylvester H Chuang; Sheelagh M Kemp; James T Rutka; O Carter Snead; Hiroshi Otsubo
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-04-10
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  119     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-07-10     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1328-34     Citation Subset:  IM    
Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont., Canada M5G-1X8.
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MeSH Terms
Analysis of Variance
Anesthesia / methods*
Anesthesia, Intravenous / methods*
Brain Mapping*
Chi-Square Distribution
Child, Preschool
Electric Stimulation / methods
Epilepsy / diagnosis*,  physiopathology*
Evoked Potentials, Somatosensory / drug effects,  physiology*
Median Nerve / physiopathology,  radiation effects
Reaction Time

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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