Document Detail


Somatomedin-like activity, prolactin, growth hormone and insulin in human cord blood.
MedLine Citation:
PMID:  229818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to assess the possible influence of fetal polypeptide hormones on birth size, somatomedin-like receptor activity (SmLRA) (n = 281), prolactin (n = 158), growth hormone (n = 133) and insulin (n = 108) concentrations were measured in the cord blood of 281 singleton infants born after different complications of pregnancy. Infant sex did not significantly affect the concentration of any hormone. SmLRA concentrations appeared to rise from 25 to 38 weeks of gestation, but thereafter fell. Concentrations of prolactin, growth hormone and insulin correlated negatively with gestational age. Insulin emerged as the hormone most clearly related to fetal growth, since concentrations were high (mean +/- SD = 20.6 +/- 11.5 uU/ml) in serum from infants of diabetic mothers (IDM) and other large-for-dates infants (10.1 +/- 4.8 uU/ml), but low (5.3 +/- 0.5 uU/ml) in infants who were small-for-dates (SFD). In contrast, SmLRA concentrations were high in serum from SFD infants (0.63 +/- 0.29 U/ml) and low in IDM (0.43 +/- 0.16 U/ml). Prolactin concentrations were higher in serum from SFD infants (212 +/- 101 ng/ml) and from IDM (237 +/- 182 ng/ml) than from normal infants born at term (139 +/- 68 ng/ml). Administration of intramuscular betamethasone to pregnant women in premature labour resulted in significant elevations in the concentrations of prolactin and insulin in cord blood.
Authors:
M W Brinsmead; G C Liggins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  19     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / pharmacology
Birth Weight
Female
Fetal Blood / metabolism*
Gestational Age
Growth Hormone / blood*
Humans
Hypertension / complications
Infant, Newborn
Infant, Small for Gestational Age
Insulin / blood*
Pregnancy
Pregnancy Complications
Pregnancy Complications, Cardiovascular
Pregnancy in Diabetics / complications
Prolactin / blood*
Radioligand Assay
Receptors, Cell Surface
Sex Factors
Somatomedins / blood*
Twins
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Receptors, Cell Surface; 0/Somatomedins; 11061-68-0/Insulin; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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