| Somatomedin-like activity, prolactin, growth hormone and insulin in human cord blood. | |
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MedLine Citation:
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PMID: 229818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to assess the possible influence of fetal polypeptide hormones on birth size, somatomedin-like receptor activity (SmLRA) (n = 281), prolactin (n = 158), growth hormone (n = 133) and insulin (n = 108) concentrations were measured in the cord blood of 281 singleton infants born after different complications of pregnancy. Infant sex did not significantly affect the concentration of any hormone. SmLRA concentrations appeared to rise from 25 to 38 weeks of gestation, but thereafter fell. Concentrations of prolactin, growth hormone and insulin correlated negatively with gestational age. Insulin emerged as the hormone most clearly related to fetal growth, since concentrations were high (mean +/- SD = 20.6 +/- 11.5 uU/ml) in serum from infants of diabetic mothers (IDM) and other large-for-dates infants (10.1 +/- 4.8 uU/ml), but low (5.3 +/- 0.5 uU/ml) in infants who were small-for-dates (SFD). In contrast, SmLRA concentrations were high in serum from SFD infants (0.63 +/- 0.29 U/ml) and low in IDM (0.43 +/- 0.16 U/ml). Prolactin concentrations were higher in serum from SFD infants (212 +/- 101 ng/ml) and from IDM (237 +/- 182 ng/ml) than from normal infants born at term (139 +/- 68 ng/ml). Administration of intramuscular betamethasone to pregnant women in premature labour resulted in significant elevations in the concentrations of prolactin and insulin in cord blood. |
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Authors:
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M W Brinsmead; G C Liggins |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Australian & New Zealand journal of obstetrics & gynaecology Volume: 19 ISSN: 0004-8666 ISO Abbreviation: Aust N Z J Obstet Gynaecol Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1980-02-28 Completed Date: 1980-02-28 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0001027 Medline TA: Aust N Z J Obstet Gynaecol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 129-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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pharmacology Birth Weight Female Fetal Blood / metabolism* Gestational Age Growth Hormone / blood* Humans Hypertension / complications Infant, Newborn Infant, Small for Gestational Age Insulin / blood* Pregnancy Pregnancy Complications Pregnancy Complications, Cardiovascular Pregnancy in Diabetics / complications Prolactin / blood* Radioligand Assay Receptors, Cell Surface Sex Factors Somatomedins / blood* Twins |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Receptors, Cell Surface; 0/Somatomedins; 11061-68-0/Insulin; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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