Document Detail

Somatomedin-C levels related to gestational age, birth weight and day of life.
MedLine Citation:
PMID:  3769973     Owner:  NLM     Status:  MEDLINE    
Capillary blood samples on filter paper were assayed by means of an RIA method (Kit Nichols Institute USA) from 1096 newborns divided into full term, preterm and small-for-date infants. The somatomedin-C (Sm-C) mean value, which did not differ in the three groups, was 0.15 +/- 0.09 IU/ml. One hundred and ten (10%) showed Sm-C disc values less than or equal to 0.075 IU/ml, the minimum value measurable by our method. The day of life and birth weight had a significant influence on Sm-C levels. Gestational age did not have any significant effect. No significant interaction was found among the parameters considered. All the groups presented a progressive increase of Sm-C. Unlike preterm and small-for-date infants, in full term infants the latter increase seemed already to be evident from 5th day of life and reached higher levels from the 7th day of life onwards. In conclusion, Sm-C rates were reduced in the neonatal phase of life, but showed a tendency to rise later.
A Cassio; M Capelli; E Cacciari; A Cicognani; P Pirazzoli; F Righetti; D Ballardini; G Natali; S Zucchini; E Martelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pediatrics     Volume:  145     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-12-09     Completed Date:  1986-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  187-9     Citation Subset:  IM    
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MeSH Terms
Age Factors
Birth Weight*
Gestational Age*
Infant, Newborn / blood
Infant, Premature / blood
Infant, Small for Gestational Age / blood
Insulin-Like Growth Factor I / blood*
Somatomedins / blood*
Reg. No./Substance:
0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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