Document Detail

Somatomedin-C in accelerated growth of children with precocious puberty.
MedLine Citation:
PMID:  3891947     Owner:  NLM     Status:  MEDLINE    
To assess the role of somatomedin-C as a possible mediator of the growth spurt in children with central precocious puberty, we compared Sm-C levels in 40 children with central precocious puberty, 87 age-matched normal children, and 110 normal pubertal controls. Somatomedin C levels were significantly elevated for age in the children with precocious puberty (P less than 0.01), and were similar to the levels observed during normal puberty. The patients with precocious puberty were given the luteinizing hormone releasing hormone analogue D-Trp6-Pro9-NEt-LHRH (LHRHa) for 6 months. Treatment caused a significant decrease in secondary sexual characteristics, growth rate, plasma gonadotropins, sex steroids (estradiol in the girls and testosterone in the boys), and Sm-C levels. Growth during LHRHa treatment returned to the age-appropriate rate, whereas plasma Sm-C levels, although lower than pretreatment levels, remained significantly elevated for age (P less than 0.002). In addition, growth rates before and during treatment did not correlate with the plasma somatomedin C levels, nor did the decreases in growth rate during LHRHa therapy correlate with the decreases in somatomedin C levels. Growth rates did correlate significantly, however, with plasma estradiol levels in the girls (P less than 0.0005) and with plasma testosterone levels in the boys (P less than 0.025). We conclude that the growth spurt in children with precocious puberty cannot be explained by the plasma level of somatomedin C.
O H Pescovitz; R G Rosenfeld; R L Hintz; K Barnes; K Hench; F Comite; D L Loriaux; G B Cutler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  107     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-16     Completed Date:  1985-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-5     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Estradiol / blood
Gonadotropin-Releasing Hormone / therapeutic use
Growth / drug effects
Growth Disorders / blood*,  etiology
Insulin / blood
Insulin-Like Growth Factor I
Peptides / blood
Puberty, Precocious / blood*,  complications,  drug therapy
Sex Characteristics
Somatomedins / blood*
Testosterone / blood
Reg. No./Substance:
0/Peptides; 0/Somatomedins; 11061-68-0/Insulin; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 58-22-0/Testosterone; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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