| Somatic and reflex development in suckling rats: effects of mother treatment with ketogenic diet associated with lack of protein. | |
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MedLine Citation:
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PMID: 19925719 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Ketogenic diets influence brain function and have been therapeutically used for anti-epileptic purposes. We investigated the effects of maternal ketogenic diets on the development of somatic and reflex responses in rat pups. These were born from mothers receiving: (i) normal fat (7%) + normal protein (17%); (ii) high-fat (55.4%) + normal protein; (iii) normal fat + low protein (8%); and (iv) high-fat + low protein (respectively, called N-17, K-17, N-8 and K-8). Ketogenic diets, but not the normal-fat diets, delayed the development of reflex and somatic responses. The effects were more evident when the ketogenic diet was associated with low protein content. The results suggest that fat excess can alter brain maturation, and this action is intensified by early protein-deficiency. Data raise concerns about the therapeutic use of ketogenic diets in newborn children. |
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Authors:
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Ana Karla Ferrer Soares; Renata G S Guerra; Mylena Lucena de Castro; Angela Amancio-dos-Santos; Rubem Carlos Araújo Guedes; José Eulálio Cabral-Filho; José Audísio Costa; Maria do Carmo Medeiros |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutritional neuroscience Volume: 12 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 260-6 Citation Subset: IM |
Affiliation:
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Departamento de Nutrição, Universidade Federal de Pernambuco, 50670-901 Recife, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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