Document Detail


Somatic cell-germ cell relationships in mammalian testes during development and spermatogenesis.
MedLine Citation:
PMID:  7835155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the mammalian testis, somatic cells under hormonal regulation greatly influence the different stages of spermatogenesis, both in intermittent breeders and in animals which produce sperm continuously. In turn, specific populations of germinal cells modulate the function of Sertoli cells, the chief somatic cells within mammalian seminiferous tubules. Tubule formation can take place in the absence of germinal cells. Unlike homologous granulosa cells in the ovary, Sertoli cells retain many of their usual functions in germ cell-free animals. Some of the properties of Sertoli cells and their responses to stimulation by androgens or follicle-stimulating hormone are dependent upon information transmitted from neighbouring germinal cells at specific stages of the cycle of the seminiferous epithelium. We review the roles of some of the growth factors and paracrine agents synthesized and secreted by different classes of testicular cells. The potential roles of some of the known factors secreted by Sertoli cells (e.g. activin, inhibin, anti-Müllerian hormones, TGF-beta and somatomedin C) are considered in relation to the control of tubule formation, spermatogonial proliferation and cytodifferentiation, meiosis and the subsequent stages of spermatogenesis. We stress the importance of the unique tubule cytoarchitecture within which cell interactions take place and the changing nature of this cytoarchitecture at different stages of gonadal maturation.
Authors:
I B Fritz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  182     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1994  
Date Detail:
Created Date:  1995-02-27     Completed Date:  1995-02-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  271-4; discussion 274-81     Citation Subset:  IM    
Affiliation:
Department of Cellular Physiology, AFRC Babraham Research Institute, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Leydig Cells / cytology*
Male
Mammals / physiology*
Sertoli Cells / cytology*
Sexual Maturation
Spermatogenesis*
Spermatogonia / cytology
Stem Cells / cytology
Testis / cytology,  growth & development*,  physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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