Document Detail


Solvolysis study of cycliciminomitomycins.
MedLine Citation:
PMID:  17329899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The solvolysis rates for the substituted C(7)-cyclohexylamino- or C(8)-cyclohexyliminomitomycins 8-19 were determined in buffered methanolic solutions (0.06 M bis-Tris.HCl, pH: 5.5) at 25 degrees C and then compared with mitomycin C (1) and porfiromycin. Kinetic studies showed that C(8)-cyclohexyliminomitomycins 8-13 underwent solvolysis 150-230 times faster than mitomycin C (1) to give C(1)-methoxymitosene products. The solvolysis rates were slightly faster than that reported for 6. The C(7)-(2'-hydroxy)cyclohexylaminomitomycins 16-19 exhibited comparable solvolysis rates with 1 and porfiromycin.
Authors:
Younghwa Na
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  55     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-01     Completed Date:  2007-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  482-7     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Korea. yna7315@cu.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Hydrolysis
Mitomycins / chemistry*
Molecular Structure
Chemical
Reg. No./Substance:
0/Mitomycins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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