Document Detail


Solving an ethical issue involved in experimentation with animals in a brazilian teaching laboratory*.
MedLine Citation:
PMID:  21706763     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Changes are occurring within Brazilian institutes of higher education; currently several universities are reviewing their course offerings and teaching approaches to determine if they meet the needs of today's undergraduate students. When changes are made to the curriculum of experimental courses, there should be an understood guarantee that all efforts to avoid ethical and biosafety issues have been diligently considered. Ethical considerations lead us to create an alternative experimental session to be conducted that eliminated the use of rats, the conventional in vivo model employed for learning metabolism of glycogen in our university. To avoid possible biosafety issues, we prepared an alternative sample to simulate human urine, which we called guarurine. Using our new method, it is possible to verify positive results imitating a diabetic and starving people samples for detection of glucose and ketone. The alternative tool described herein is not only particularly suited to bypass the ethics of using animals for teaching, but also permits the discussion of significant aspects of pathological and physiological situations such as diabetics and starvation in a simple, safe, and interesting way.
Authors:
Natália I V Loureiro; Henrique V Viana; Carlos R Rodrigues; Lúcio Mendes Cabral; Thaís D N Silva; Fernanda Serpa Cardoso; Dilvani Oliveira Santos; Helena C Castro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology     Volume:  32     ISSN:  1470-8175     ISO Abbreviation:  Biochem Mol Biol Educ     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100970605     Medline TA:  Biochem Mol Biol Educ     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  -    
Copyright Information:
Copyright © 2004 International Union of Biochemistry and Molecular Biology, Inc.
Affiliation:
LaBioMol, Instituto Biologia, Universidade Federal Fluminense, RJ, 24001-970, Brazil.
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