| Solvent-slaved protein motions accompany proton but not hydride tunneling in light-activated protochlorophyllide oxidoreductase. | |
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MedLine Citation:
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PMID: 19373814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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H(+) but not H(-): The reduction reaction of protochlorophyllide catalyzed by protochlorophyllide oxidoreductase features solvent-slaved motions that control the proton- but not the hydride-tunneling mechanism. These motions imply a long-range dynamic network from the solvent to the enzyme active site that facilitate proton transfer (see picture, left). Motions for hydride transfer are more localized and are not slaved by the solvent (see picture, right). |
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Authors:
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Derren J Heyes; Michiyo Sakuma; Nigel S Scrutton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: 48 ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: Germany |
Other Details:
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Languages: eng Pagination: 3850-3 Citation Subset: IM |
Affiliation:
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Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. derren.heyes@manchester.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyanobacteria
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enzymology Enzyme Activation / radiation effects Hydrogen / chemistry* Light Molecular Structure Oxidoreductases Acting on CH-CH Group Donors / metabolism* Photochemical Processes Protons* Solvents / chemistry* Viscosity |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Protons; 0/Solvents; 1333-74-0/Hydrogen; EC 1.3.-/Oxidoreductases Acting on CH-CH Group Donors; EC 1.3.1.33/protochlorophyllide reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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