| Solvent selection for biocatalysis in mainly organic systems: predictions of effects on equilibrium position. | |
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MedLine Citation:
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PMID: 18592565 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Predictions may be made for the influence of solvent choice on the equilibrium position of biocatalyzed reactions, based on data for the liquid-liquid distribution of the reactants. The most reliable predictions are probably for dilute systems, based on partition coefficients or correlations derived from them. The effective equilibrium constant for esterification reactions is predicted to alter by more than four orders of magnitude on changing between different water-immiscible solvents. The equilibrium constant correlates well with the solubility of water in the solvent, and is most favorable for synthesis in the least polar solvents (aliphatic hydrocarbons). Similar effects seem to apply for other reactions, including oxidation of alcohols and hydrolysis of chlorides. Predictions can be made for nondilute systems using the UNIFAC system of group contributions, but the reliability of these is more questionable. |
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Authors:
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P J Halling |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 35 ISSN: 0006-3592 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 2008-07-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 691-701 Citation Subset: - |
Affiliation:
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Department of Bioscience & Biotechnology, University of Strathclyde, Glasgow G1 1XW, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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