Document Detail


Solvent exposures and Parkinson disease risk in twins.
MedLine Citation:
PMID:  22083847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.
METHODS: Ninety-nine twin pairs discordant for PD ascertained from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job task-specific questionnaires. Exposures to 6 specific solvents selected a priori were estimated by expert raters unaware of case status.
RESULTS: Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (odds ratio [OR], 6.1; 95% confidence interval [CI] 1.2-33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl(4) ) tended toward significance (respectively: OR, 10.5; 95% CI, 0.97-113; p = 0.053; OR, 2.3; 95% CI, 0.9-6.1; p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure.
INTERPRETATION: Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl(4) are also ubiquitous in the environment. Our findings require replication in other populations with well-characterized exposures, but the potential public health implications are substantial.
Authors:
Samuel M Goldman; Patricia J Quinlan; G Webster Ross; Connie Marras; Cheryl Meng; Grace S Bhudhikanok; Kathleen Comyns; Monica Korell; Anabel R Chade; Meike Kasten; Benjamin Priestley; Kelvin L Chou; Hubert H Fernandez; Franca Cambi; J William Langston; Caroline M Tanner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-14
Journal Detail:
Title:  Annals of neurology     Volume:  71     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-21     Completed Date:  2012-08-30     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  776-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Neurological Association.
Affiliation:
The Parkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, USA. sgoldman@thepi.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carbon Tetrachloride / toxicity
Cohort Studies
Diseases in Twins / epidemiology*
Female
Humans
Male
Middle Aged
Occupational Exposure / adverse effects*
Odds Ratio
Parkinson Disease / epidemiology*,  etiology*
Risk Factors
Solvents / toxicity*
Tetrachloroethylene / toxicity
Twins
Grant Support
ID/Acronym/Agency:
R01 NS040467/NS/NINDS NIH HHS; R01 NS040467-01/NS/NINDS NIH HHS; R01-NS40467/NS/NINDS NIH HHS; U10 NS031321-03/NS/NINDS NIH HHS; U10-NS31321/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Solvents; 127-18-4/Tetrachloroethylene; 56-23-5/Carbon Tetrachloride
Comments/Corrections
Comment In:
Ann Neurol. 2012 Aug;72(2):294; author reply 294-5   [PMID:  22926860 ]
Ann Neurol. 2012 Dec;72(6):984   [PMID:  23280848 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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