Document Detail

Solution to the problem of interferences in electrochemical sensors using the fill-and-flow channel biosensor.
MedLine Citation:
PMID:  12585489     Owner:  NLM     Status:  MEDLINE    
A generic fill-and-flow channel biosensor with upstream electrodes to determine the extent of interferences in the sample is described. A pair of upstream electrodes poised at a suitable potential allows both the calculation of the extent of removal of interfering agents and the effect of interfering agents at the detector electrode. A model was developed and tested that predicts the concentrations of all species throughout the channel and, hence, the current at each electrode due to each species. This enables correction of the detector electrode current and a more accurate determination of the analyte concentration. The concept was applied to a biosensor for the determination of glucose in the presence of ascorbic acid, acetamidophenol, and uric acid, as well as glucose in wine samples containing polyphenolic interfering agents.
Min Zhao; D Brynn Hibbert; J Justin Gooding
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Analytical chemistry     Volume:  75     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-14     Completed Date:  2003-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-600     Citation Subset:  IM    
School of Chemical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
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MeSH Terms
Ascorbic Acid
Biosensing Techniques / methods*,  standards
Electrodes / standards
Glucose / analysis
Wine / analysis
Reg. No./Substance:
50-81-7/Ascorbic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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