Document Detail


Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops.
MedLine Citation:
PMID:  22532609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We herein report on the formation and high-resolution NMR solution-state structure determination of a G-quadruplex adopted by d[G(3)ATG(3)ACACAG(4)ACG(3)] comprised of four G-tracts with the third one consisting of four guanines that are intervened with non-G streches of different lengths. A single intramolecular antiparallel (3+1) G-quadruplex exhibits three stacked G-quartets connected with propeller, diagonal and edgewise loops of different lengths. The propeller and edgewise loops are well structured, whereas the longer diagonal loop is more flexible. To the best of our knowledge, this is the first high-resolution G-quadruplex structure where all of the three main loop types are present.
Authors:
Maja Marusic; Primoz Sket; Lubos Bauer; Viktor Viglasky; Janez Plavec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-24
Journal Detail:
Title:  Nucleic acids research     Volume:  40     ISSN:  1362-4962     ISO Abbreviation:  Nucleic Acids Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-08     Completed Date:  2012-11-05     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0411011     Medline TA:  Nucleic Acids Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  6946-56     Citation Subset:  IM    
Affiliation:
Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, Slovenia.
Data Bank Information
Bank Name/Acc. No.:
PDB/2LOD
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MeSH Terms
Descriptor/Qualifier:
DNA / chemistry*
G-Quadruplexes*
Models, Molecular
Nuclear Magnetic Resonance, Biomolecular
Oligonucleotides / chemistry
Potassium / chemistry
Chemical
Reg. No./Substance:
0/Oligonucleotides; 7440-09-7/Potassium; 9007-49-2/DNA
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