Document Detail

Solution-phase synthesis of a combinatorial library of 3-[4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides.
MedLine Citation:
PMID:  18007316     Owner:  NLM     Status:  MEDLINE    
The parallel solution-phase synthesis of a new combinatorial library of 3-[4-(R1-coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides 9 has been developed. The synthesis involves two steps: 1) the synthesis of core building blocks - 3- [4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acids, 6 - by the reaction of 3-(omega-bromacetyl)coumarins 1 with 3-amino(thioxo)methylcarbamoylpropanoic acid (5); 2) the synthesis of the corresponding 3-[4-(coumarin-3-yl)-1,3-thiazol-2-yl- carbamoyl]propanoic acids amides 9 using 1,1'-carbonyldimidazole as a coupling reagent. The advantages of the method compared to existing ones are discussed.
Irina O Zhuravel; Sergiy M Kovalenko; Sergiy V Vlasov; Valentin P Chernykh
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2005-02-28
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  10     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2005  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-29     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  444-56     Citation Subset:  IM    
National Pharmaceutical University, Kharkiv, Ukraine.
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MeSH Terms
Amides / chemical synthesis*
Combinatorial Chemistry Techniques*
Coumarins / chemical synthesis*,  chemistry
Models, Biological
Propionic Acids / chemical synthesis*,  chemistry
Small Molecule Libraries / chemical synthesis*
Solutions / chemistry*
Reg. No./Substance:
0/Amides; 0/Coumarins; 0/Propionic Acids; 0/Small Molecule Libraries; 0/Solutions

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