| Solution-phase synthesis of a combinatorial library of 3-[4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides. | |
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MedLine Citation:
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PMID: 18007316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The parallel solution-phase synthesis of a new combinatorial library of 3-[4-(R1-coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides 9 has been developed. The synthesis involves two steps: 1) the synthesis of core building blocks - 3- [4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acids, 6 - by the reaction of 3-(omega-bromacetyl)coumarins 1 with 3-amino(thioxo)methylcarbamoylpropanoic acid (5); 2) the synthesis of the corresponding 3-[4-(coumarin-3-yl)-1,3-thiazol-2-yl- carbamoyl]propanoic acids amides 9 using 1,1'-carbonyldimidazole as a coupling reagent. The advantages of the method compared to existing ones are discussed. |
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Authors:
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Irina O Zhuravel; Sergiy M Kovalenko; Sergiy V Vlasov; Valentin P Chernykh |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2005-02-28 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 10 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2005 |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-01-29 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 444-56 Citation Subset: IM |
Affiliation:
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National Pharmaceutical University, Kharkiv, Ukraine. kosn@ic.kharkov.ua. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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chemical synthesis* Combinatorial Chemistry Techniques* Coumarins / chemical synthesis*, chemistry Models, Biological Propionic Acids / chemical synthesis*, chemistry Small Molecule Libraries / chemical synthesis* Solutions / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Coumarins; 0/Propionic Acids; 0/Small Molecule Libraries; 0/Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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