Document Detail

Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates.
MedLine Citation:
PMID:  16337100     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis. AIM: To study the implication of sVEGFR-1-a VEGF antagonist-in IUGR. STUDY DESIGN: Prospective study. METHODS: Twenty-five IUGR and 15 appropriate for gestational age (AGA) full-term fetuses and neonates with their mothers were included in the study. OUTCOME MEASURES: sVEGFR-1 levels were determined by enzyme immunoassay in the serum of: mothers (MS), umbilical cords (UC)-representing fetal state - and neonates on day 1 (N1) and 4 (N4) of life. RESULTS: MS, UC, N1 and N4 sVEGFR-1 levels in IUGR were significantly higher compared to respective AGA cases (p = 0.005, p = 0.026, p = 0.005 and p = 0.017, respectively). In IUGR and AGA groups, maternal sVEGFR-1 levels were significantly higher than fetal and neonatal levels (p in all cases < 0.001). The latter presented in both IUGR and AGA groups a significant decrease from UC to N4 (p in all cases < 0.01). MS, N1 and N4 sVEGFR-1 levels negatively correlated with the infants' customized centiles [(r = -0.489, p = 0.001), (r = -0.440, p = 0.004), (r = -0.431, p = 0.006), respectively]. CONCLUSIONS: Higher sVEGFR-1 levels in the IUGR as compared to the AGA group possibly reflect the predominance of antiangiogenic mechanisms present in IUGR. The decrease of sVEGFR-1 levels from UC to N4 may represent ex utero initiation of growth and development and therefore, prevalence of angiogenic mechanisms.
Theodora Boutsikou; Ariadne Malamitsi-Puchner; Emmanuel Economou; Maria Boutsikou; Karl-Philipp Puchner; Dimitrios Hassiakos
Publication Detail:
Type:  Journal Article     Date:  2005-12-05
Journal Detail:
Title:  Early human development     Volume:  82     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-07-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Neonatal Division, 2nd Department of Obstetrics and Gynecology, University of Athens 19, Soultani Str GR-10682, Athens, Greece.
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MeSH Terms
Fetal Blood / metabolism
Fetal Growth Retardation / blood*
Fetus / metabolism*
Gestational Age
Infant, Newborn / blood*
Pregnancy / blood
Prospective Studies
Reference Values
Vascular Endothelial Growth Factor Receptor-1 / blood*
Reg. No./Substance:
EC Endothelial Growth Factor Receptor-1

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