Document Detail


Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop.
MedLine Citation:
PMID:  15507947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was undertaken to analyze prospectively circulating vascular endothelial growth factor (VEGF) and its soluble receptor, (s) Flt-1, throughout normotensive and preeclamptic pregnancies and to assess the importance of these proteins in the development of preeclampsia. STUDY DESIGN: In this longitudinal cohort study, serum samples were collected from recruited subjects throughout pregnancy at 12, 20, 30, and 37 weeks and in the 24 hours before and after delivery. Subjects were divided retrospectively into normotensive and preeclamptic groups. Circulating VEGF and sFlt-1 concentrations were analyzed by radioimmunoassay and enzyme-linked immunosorbent assay, respectively. RESULTS: Circulating sFlt-1 and VEGF significantly increased as gestation progressed and both were further elevated in preeclampsia compared with normotensive pregnancy. Soluble Flt-1 concentrations were elevated early in gestation and were significantly increased at 30 weeks' gestation in those who subsequently developed preeclampsia. CONCLUSION: These results indicate a definite association between elevated sFlt-1 concentrations and the onset of preeclampsia suggesting that sFlt-1 is linked with disease pathogenesis.
Authors:
Gareth C McKeeman; Joy E S Ardill; Carolyn M Caldwell; Alyson J Hunter; Neil McClure
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-27     Completed Date:  2004-12-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1240-6     Citation Subset:  AIM; IM    
Affiliation:
School of Medicine, Obstetrics and Gynecology, Institute of Clinical Science, Queen's University Belfast, Mulhouse Building, Grosvenort Road, Belfast BT12 6BW, Ireland. g.mckeeman@qub.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Pre-Eclampsia / blood*
Pregnancy / blood*
Prospective Studies
Vascular Endothelial Growth Factor A / blood
Vascular Endothelial Growth Factor Receptor-1 / blood*
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):896; author reply 896-7   [PMID:  16150304 ]
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):895-6; author reply 896-7   [PMID:  16150302 ]

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